Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients

Yasuhiro Suzuki; Sin Yew Wong; F. Carl Grumet; Jeffrey Fessel; Jose G. Montoya; Andrew R. Zolopa; Amy Portmore; Françoise Schumacher-Perdreau; Matthias Schrappe; Stefan K̈ppen; Bernhard Ruf; Byron William Brown; Jack S. Remington

doi:10.1093/infdis/173.1.265

Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients

Yasuhiro Suzuki, Sin Yew Wong, F. Carl Grumet, Jeffrey Fessel, Jose G. Montoya, Andrew R. Zolopa, Amy Portmore, Françoise Schumacher-Perdreau, Matthias Schrappe, Stefan K̈ppen, Bernhard Ruf, Byron William Brown, Jack S. Remington

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent in white North American AIDS patients with TE (85.0%) than in the general white population (51.8%; P = .007, corrected P = .028) or randomly selected control AIDS patients who had not developed TE (40.0%; P = .016). In contrast, the frequency of HLA-DQ1 was lower in TE patients than in healthy controls (40.0% vs. 66.5%, P = .027), but this difference did not reach statistical significance when corrected for the number of variables tested (corrected P = .108 for the general white population). HLA-DQ3 thus appears to be a genetic marker of susceptibility to development of TE in AIDS patients, and DQ1 may be a resistance marker. These HLA associations with disease indicate that development of TE in AIDS patients is affected by a gene or genes in the HLA complex and that HLA-DQ typing may help in decisions regarding TE prophylaxis.

Original language	English
Pages (from-to)	265-268
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	173
Issue number	1
DOIs	https://doi.org/10.1093/infdis/173.1.265
State	Published - 1996

Bibliographical note

Funding Information:
Received 17 January 1995; revised 17 July 1995. Financial support: Japan Immunoresearch Company; National Institutes of Health (AI-04717 and HL-33811); and Health Manpower Development Plan scholarship, Ministry of Health, Singapore (to S.-Y.W.). Reprints or correspondence: Dr. Jack S. Remington, Dept. of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, CA 94301. • Current affiliation: Department ofInfectious Diseases, Communicable Disease Center, Tan Tock Seng Hospital, Singapore (S.-Y.W.); Staedtisches Krankenhaus Hildesheim 31134, Hildesheim, Germany (S.K.).

Funding

Received 17 January 1995; revised 17 July 1995. Financial support: Japan Immunoresearch Company; National Institutes of Health (AI-04717 and HL-33811); and Health Manpower Development Plan scholarship, Ministry of Health, Singapore (to S.-Y.W.). Reprints or correspondence: Dr. Jack S. Remington, Dept. of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, CA 94301. • Current affiliation: Department ofInfectious Diseases, Communicable Disease Center, Tan Tock Seng Hospital, Singapore (S.-Y.W.); Staedtisches Krankenhaus Hildesheim 31134, Hildesheim, Germany (S.K.).

Funders	Funder number
Japan Immunoresearch Company
Ministry of Health, Government of Singapore
National Institutes of Health (NIH)	HL-33811
National Institute of Allergy and Infectious Diseases	R37AI004717

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/173.1.265

Cite this

Suzuki, Y., Wong, S. Y., Carl Grumet, F., Fessel, J., Montoya, J. G., Zolopa, A. R., Portmore, A., Schumacher-Perdreau, F., Schrappe, M., K̈ppen, S., Ruf, B., Brown, B. W., & Remington, J. S. (1996). Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients. Journal of Infectious Diseases, 173(1), 265-268. https://doi.org/10.1093/infdis/173.1.265

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title = "Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients",

abstract = "The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent in white North American AIDS patients with TE (85.0%) than in the general white population (51.8%; P = .007, corrected P = .028) or randomly selected control AIDS patients who had not developed TE (40.0%; P = .016). In contrast, the frequency of HLA-DQ1 was lower in TE patients than in healthy controls (40.0% vs. 66.5%, P = .027), but this difference did not reach statistical significance when corrected for the number of variables tested (corrected P = .108 for the general white population). HLA-DQ3 thus appears to be a genetic marker of susceptibility to development of TE in AIDS patients, and DQ1 may be a resistance marker. These HLA associations with disease indicate that development of TE in AIDS patients is affected by a gene or genes in the HLA complex and that HLA-DQ typing may help in decisions regarding TE prophylaxis.",

author = "Yasuhiro Suzuki and Wong, {Sin Yew} and {Carl Grumet}, F. and Jeffrey Fessel and Montoya, {Jose G.} and Zolopa, {Andrew R.} and Amy Portmore and Fran{\c c}oise Schumacher-Perdreau and Matthias Schrappe and Stefan {\"K}ppen and Bernhard Ruf and Brown, {Byron William} and Remington, {Jack S.}",

note = "Funding Information: Received 17 January 1995; revised 17 July 1995. Financial support: Japan Immunoresearch Company; National Institutes of Health (AI-04717 and HL-33811); and Health Manpower Development Plan scholarship, Ministry of Health, Singapore (to S.-Y.W.). Reprints or correspondence: Dr. Jack S. Remington, Dept. of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, CA 94301. • Current affiliation: Department ofInfectious Diseases, Communicable Disease Center, Tan Tock Seng Hospital, Singapore (S.-Y.W.); Staedtisches Krankenhaus Hildesheim 31134, Hildesheim, Germany (S.K.).",

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Suzuki, Y, Wong, SY, Carl Grumet, F, Fessel, J, Montoya, JG, Zolopa, AR, Portmore, A, Schumacher-Perdreau, F, Schrappe, M, K̈ppen, S, Ruf, B, Brown, BW & Remington, JS 1996, 'Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients', Journal of Infectious Diseases, vol. 173, no. 1, pp. 265-268. https://doi.org/10.1093/infdis/173.1.265

TY - JOUR

T1 - Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients

AU - Suzuki, Yasuhiro

AU - Wong, Sin Yew

AU - Carl Grumet, F.

AU - Fessel, Jeffrey

AU - Montoya, Jose G.

AU - Zolopa, Andrew R.

AU - Portmore, Amy

AU - Schumacher-Perdreau, Françoise

AU - Schrappe, Matthias

AU - K̈ppen, Stefan

AU - Ruf, Bernhard

AU - Brown, Byron William

AU - Remington, Jack S.

N1 - Funding Information: Received 17 January 1995; revised 17 July 1995. Financial support: Japan Immunoresearch Company; National Institutes of Health (AI-04717 and HL-33811); and Health Manpower Development Plan scholarship, Ministry of Health, Singapore (to S.-Y.W.). Reprints or correspondence: Dr. Jack S. Remington, Dept. of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, CA 94301. • Current affiliation: Department ofInfectious Diseases, Communicable Disease Center, Tan Tock Seng Hospital, Singapore (S.-Y.W.); Staedtisches Krankenhaus Hildesheim 31134, Hildesheim, Germany (S.K.).

PY - 1996

Y1 - 1996

N2 - The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent in white North American AIDS patients with TE (85.0%) than in the general white population (51.8%; P = .007, corrected P = .028) or randomly selected control AIDS patients who had not developed TE (40.0%; P = .016). In contrast, the frequency of HLA-DQ1 was lower in TE patients than in healthy controls (40.0% vs. 66.5%, P = .027), but this difference did not reach statistical significance when corrected for the number of variables tested (corrected P = .108 for the general white population). HLA-DQ3 thus appears to be a genetic marker of susceptibility to development of TE in AIDS patients, and DQ1 may be a resistance marker. These HLA associations with disease indicate that development of TE in AIDS patients is affected by a gene or genes in the HLA complex and that HLA-DQ typing may help in decisions regarding TE prophylaxis.

AB - The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent in white North American AIDS patients with TE (85.0%) than in the general white population (51.8%; P = .007, corrected P = .028) or randomly selected control AIDS patients who had not developed TE (40.0%; P = .016). In contrast, the frequency of HLA-DQ1 was lower in TE patients than in healthy controls (40.0% vs. 66.5%, P = .027), but this difference did not reach statistical significance when corrected for the number of variables tested (corrected P = .108 for the general white population). HLA-DQ3 thus appears to be a genetic marker of susceptibility to development of TE in AIDS patients, and DQ1 may be a resistance marker. These HLA associations with disease indicate that development of TE in AIDS patients is affected by a gene or genes in the HLA complex and that HLA-DQ typing may help in decisions regarding TE prophylaxis.

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Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

Access to Document

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