Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients

Yasuhiro Suzuki, Sin Yew Wong, F. Carl Grumet, Jeffrey Fessel, Jose G. Montoya, Andrew R. Zolopa, Amy Portmore, Françoise Schumacher-Perdreau, Matthias Schrappe, Stefan K̈ppen, Bernhard Ruf, Byron William Brown, Jack S. Remington

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent in white North American AIDS patients with TE (85.0%) than in the general white population (51.8%; P = .007, corrected P = .028) or randomly selected control AIDS patients who had not developed TE (40.0%; P = .016). In contrast, the frequency of HLA-DQ1 was lower in TE patients than in healthy controls (40.0% vs. 66.5%, P = .027), but this difference did not reach statistical significance when corrected for the number of variables tested (corrected P = .108 for the general white population). HLA-DQ3 thus appears to be a genetic marker of susceptibility to development of TE in AIDS patients, and DQ1 may be a resistance marker. These HLA associations with disease indicate that development of TE in AIDS patients is affected by a gene or genes in the HLA complex and that HLA-DQ typing may help in decisions regarding TE prophylaxis.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalJournal of Infectious Diseases
Volume173
Issue number1
DOIs
StatePublished - 1996

Bibliographical note

Funding Information:
Received 17 January 1995; revised 17 July 1995. Financial support: Japan Immunoresearch Company; National Institutes of Health (AI-04717 and HL-33811); and Health Manpower Development Plan scholarship, Ministry of Health, Singapore (to S.-Y.W.). Reprints or correspondence: Dr. Jack S. Remington, Dept. of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, CA 94301. • Current affiliation: Department ofInfectious Diseases, Communicable Disease Center, Tan Tock Seng Hospital, Singapore (S.-Y.W.); Staedtisches Krankenhaus Hildesheim 31134, Hildesheim, Germany (S.K.).

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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