Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment

Sarah B. Martin, Charles D. Smith, Heather R. Collins, Fred A. Schmitt, Brian T. Gold

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


The present study sought to determine if volumes of specific brain structures could discriminate cognitively normal seniors destined to develop mild cognitive impairment (MCI) within a few years from those who will remain normal. Brain scans were collected from seventy-one cognitively normal seniors. Seventeen individuals later developed MCI (the presymptomatic MCI; pMCI group), while fifty-four remained normal. Whole brain volume (WBV) and volumes of the entorhinal cortex (ERC), hippocampus, and three subregions of the hippocampus (head; HH, body; HB and tail; HT) were compared. Results indicated that the pMCI group had smaller volumes than the normal group in the ERC, HH and HB, but not the HT or WBV. When HH/HB volumes and baseline memory test scores were included in a single logistic regression model, classification accuracy was very high (area under the curve = 0.93). These results show that smaller normalized volumes of anterior medial temporal lobe structures contribute to the development of MCI, a finding which may have implications for identifying seniors at risk for cognitive decline.

Original languageEnglish
Pages (from-to)1099-1106
Number of pages8
JournalNeurobiology of Aging
Issue number7
StatePublished - Jul 2010

Bibliographical note

Funding Information:
This research was supported by National Institutes of Health grants NS03660, P50 AG05144 and T32 AG00242. The authors thank Agnes Bognar for technical assistance, and Drs. William Markesbery, Dave Wekstein and Greg Cooper for aiding subject recruitment in our longitudinal aging study.


  • Aging
  • ERC
  • Hippocampus
  • MCI
  • Structural MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Aging
  • General Neuroscience
  • Developmental Biology


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