TY - JOUR
T1 - Evolution of Cellular Differentiation
T2 - From Hypotheses to Models
AU - Márquez-Zacarías, Pedro
AU - Pineau, Rozenn M.
AU - Gomez, Marcella
AU - Veliz-Cuba, Alan
AU - Murrugarra, David
AU - Ratcliff, William C.
AU - Niklas, Karl J.
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/1
Y1 - 2021/1
N2 - Cellular differentiation is one of the hallmarks of complex multicellularity, allowing individual organisms to capitalize on among-cell functional diversity. The evolution of multicellularity is a major evolutionary transition that allowed for the increase of organismal complexity in multiple lineages, a process that relies on the functional integration of cell-types within an individual. Multiple hypotheses have been proposed to explain the origins of cellular differentiation, but we lack a general understanding of what makes one cell-type distinct from others, and how such differentiation arises. Here, we describe how the use of Boolean networks (BNs) can aid in placing empirical findings into a coherent conceptual framework, and we emphasize some of the standing problems when interpreting data and model behaviors.
AB - Cellular differentiation is one of the hallmarks of complex multicellularity, allowing individual organisms to capitalize on among-cell functional diversity. The evolution of multicellularity is a major evolutionary transition that allowed for the increase of organismal complexity in multiple lineages, a process that relies on the functional integration of cell-types within an individual. Multiple hypotheses have been proposed to explain the origins of cellular differentiation, but we lack a general understanding of what makes one cell-type distinct from others, and how such differentiation arises. Here, we describe how the use of Boolean networks (BNs) can aid in placing empirical findings into a coherent conceptual framework, and we emphasize some of the standing problems when interpreting data and model behaviors.
KW - Boolean networks
KW - cellular differentiation
KW - dynamical systems
KW - multicellularity
UR - http://www.scopus.com/inward/record.url?scp=85089660116&partnerID=8YFLogxK
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U2 - 10.1016/j.tree.2020.07.013
DO - 10.1016/j.tree.2020.07.013
M3 - Review article
C2 - 32829916
AN - SCOPUS:85089660116
SN - 0169-5347
VL - 36
SP - 49
EP - 60
JO - Trends in Ecology and Evolution
JF - Trends in Ecology and Evolution
IS - 1
ER -