Evolution of Cellular Differentiation: From Hypotheses to Models

Pedro Márquez-Zacarías; Rozenn M. Pineau; Marcella Gomez; Alan Veliz-Cuba; David Murrugarra; William C. Ratcliff; Karl J. Niklas

doi:10.1016/j.tree.2020.07.013

Evolution of Cellular Differentiation: From Hypotheses to Models

Pedro Márquez-Zacarías
, Rozenn M. Pineau
, Marcella Gomez
, Alan Veliz-Cuba
, David Murrugarra
, William C. Ratcliff
, Karl J. Niklas

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Cellular differentiation is one of the hallmarks of complex multicellularity, allowing individual organisms to capitalize on among-cell functional diversity. The evolution of multicellularity is a major evolutionary transition that allowed for the increase of organismal complexity in multiple lineages, a process that relies on the functional integration of cell-types within an individual. Multiple hypotheses have been proposed to explain the origins of cellular differentiation, but we lack a general understanding of what makes one cell-type distinct from others, and how such differentiation arises. Here, we describe how the use of Boolean networks (BNs) can aid in placing empirical findings into a coherent conceptual framework, and we emphasize some of the standing problems when interpreting data and model behaviors.

Original language	English
Pages (from-to)	49-60
Number of pages	12
Journal	Trends in Ecology and Evolution
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.tree.2020.07.013
State	Published - Jan 2021

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

Funding

P.M-Z., R.P., M.G., A.V.C., D.M., and K.J.N. attended a summit and a follow-up workshop at the Mathematical Bioscience Institute at The Ohio State University (MBI-OSU), supported by the NSF grant DMS-1839810 , where this paper was conceived. The authors thank Matthew Thompson and Janet Best for assistance. A.V.C. received support from the Simons Foundation ( 516088 ). P.M-Z., R.P., and W.C.R. were supported by NSF grants IOS-1656549 and DEB-1845363 . P.M-Z. acknowledges the members of the Ratcliff Lab for engaging discussions on an earlier version of this manuscript.

Funders	Funder number
MBI-OSU
National Science Foundation Arctic Social Science Program	1839810, DMS-1839810
National Science Foundation Arctic Social Science Program
Simons Foundation	IOS-1656549, DEB-1845363, 516088
Simons Foundation
Ohio Water Resources Center, Ohio State University

Keywords

Boolean networks
cellular differentiation
dynamical systems
multicellularity

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics

Access to Document

10.1016/j.tree.2020.07.013

Cite this

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title = "Evolution of Cellular Differentiation: From Hypotheses to Models",

abstract = "Cellular differentiation is one of the hallmarks of complex multicellularity, allowing individual organisms to capitalize on among-cell functional diversity. The evolution of multicellularity is a major evolutionary transition that allowed for the increase of organismal complexity in multiple lineages, a process that relies on the functional integration of cell-types within an individual. Multiple hypotheses have been proposed to explain the origins of cellular differentiation, but we lack a general understanding of what makes one cell-type distinct from others, and how such differentiation arises. Here, we describe how the use of Boolean networks (BNs) can aid in placing empirical findings into a coherent conceptual framework, and we emphasize some of the standing problems when interpreting data and model behaviors.",

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AU - Márquez-Zacarías, Pedro

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AU - Gomez, Marcella

AU - Veliz-Cuba, Alan

AU - Murrugarra, David

AU - Ratcliff, William C.

AU - Niklas, Karl J.

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AB - Cellular differentiation is one of the hallmarks of complex multicellularity, allowing individual organisms to capitalize on among-cell functional diversity. The evolution of multicellularity is a major evolutionary transition that allowed for the increase of organismal complexity in multiple lineages, a process that relies on the functional integration of cell-types within an individual. Multiple hypotheses have been proposed to explain the origins of cellular differentiation, but we lack a general understanding of what makes one cell-type distinct from others, and how such differentiation arises. Here, we describe how the use of Boolean networks (BNs) can aid in placing empirical findings into a coherent conceptual framework, and we emphasize some of the standing problems when interpreting data and model behaviors.

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Evolution of Cellular Differentiation: From Hypotheses to Models

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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