Ex vivo study of telluride nanowires in minigut

Yijun Qi, Enzheng Shi, Nathan Peroutka-Bigus, Bryan Bellaire, Michael Wannemuehler, Albert Jergens, Terrence Barrett, Yue Wu, Qun Wang

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Compound semiconductor nanomaterials, such as telluride nanowires, nanorods, and nanoparticles, have many unique properties for wide range of potential applications. The interaction between organoids (a biological system) and telluride nanowires is a crucial research area for human health in terms of its safety concerns. In this study, we demonstrated a case study on Bi 2 Te 3 nanowires. Through live/dead cell viability testing, bright-light image analysis, and surface area calculations, we showed that 50μg/mL Bi 2 Te 3 exerts minimum influence on shrinking crypts and disrupting lumen structure, which causes unhealthy growth. Within this optimal concentration, Bi 2 Te 3 nanowires can stay as a stable and non-toxic material inside the intestine. Unlike the previous studies of the cytotoxicity of Telluride nanomaterials interacting with single type of cells, our research demonstrated the first study of the interactions of engineered Telluride nanomaterials with a real complex gastrointestinal tract system as our primary small intestinal crypts were directly isolated from mice and grew into a self-renewable system with various types of cells and different cell pathways, which has the capability to mimic a fully functional intestinal epithelium layer for a realistic study inside the gastrointestinal tract. Most importantly, we showed that Bi 2 Te 3 nanowires, under infrared exposure, can act as a potential shield to stimulate cell viability and improve cell survivability.

Original languageEnglish
Pages (from-to)978-986
Number of pages9
JournalJournal of Biomedical Nanotechnology
Issue number5
StatePublished - May 2018

Bibliographical note

Publisher Copyright:
Copyright © 2018 American Scientific Publishers All rights reserved.


  • Bismuth telluride
  • Minigut
  • Nanowires
  • Organoids
  • Toxicity

ASJC Scopus subject areas

  • General Medicine


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