Examining the effect of manganese on physiological processes: Invertebrate models

Cecilia Pankau, Jeremy Nadolski, Hannah Tanner, Carlie Cryer, John Di Girolamo, Christine Haddad, Matthew Lanning, Mason Miller, Devan Neely, Reece Wilson, Bre Anna Whittinghill, Robin L. Cooper

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Manganese (Mn2+ as MnSO4 &/or MnCl2) is a common and essential element for maintaining life in plants and animals and is found in soil, fresh waters and marine waters; however, over exposure is toxic to organisms. MnSO4 is added to soil for agricultural purposes and people are exposed to Mn2+ in the mining industry. Hypermanganesemia in mammals is associated with neurological issues mimicking Parkinson's disease (PD) and appears to target dopaminergic neural circuits. However, it also seems that hypermanganesemia can affect many aspects of health besides dopaminergic synapses. We examined the effect on development, behavior, survival, cardiac function, and glutamatergic synaptic transmission in the Drosophila melanogaster. In addition, we examined the effect of Mn2+ on a sensory proprioceptive organ and nerve conduction in a marine crustacean and synaptic transmission at glutamatergic neuromuscular junctions of freshwater crayfish. A dose-response effect of higher Mn2+ retards development, survival and cardiac function in larval Drosophila and survival in larvae and adults. MnSO4 as well as MnCl2 blocks stretch activated responses in primary proprioceptive neurons in a dose-response manner. Mn2+ blocks glutamatergic synaptic transmission in Drosophila as well as crayfish via presynaptic action. This study is relevant in demonstrating the effects of Mn2+ on various physiological functions in order to learn more about acute and long-term consequences Mn2+ exposure.

Original languageEnglish
Article number109209
JournalComparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
StatePublished - Jan 2022

Bibliographical note

Publisher Copyright:
© 2021


  • Cardiac
  • Crab
  • Crayfish
  • Drosophila
  • Manganese
  • Neuromuscular junction
  • Sensory
  • Survival

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Toxicology
  • Cell Biology
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Examining the effect of manganese on physiological processes: Invertebrate models'. Together they form a unique fingerprint.

Cite this