TY - JOUR
T1 - Examining the Subacute Effects of Mild Traumatic Brain Injury Using a Traditional and Computerized Neuropsychological Test Battery
AU - Karlsen, Rune Hatlestad
AU - Saksvik, Simen Berg
AU - Stenberg, Jonas
AU - Lundervold, Astri Johansen
AU - Olsen, Alexander
AU - Rautio, Ida
AU - Folvik, Line
AU - Håberg, Asta Kristine
AU - Vik, Anne
AU - Karr, Justin E.
AU - Iverson, Grant L.
AU - Skandsen, Toril
N1 - Publisher Copyright:
© 2021 Mary Ann Liebert, Inc., publishers.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - This study investigates subacute cognitive effects of mild traumatic brain injury (MTBI) in the Trondheim Mild TBI Study, as measured, in part, by the neuropsychological test battery of the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) program, including computerized tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and traditional paper-and-pencil tests. We investigated whether cognitive function was associated with injury severity: Intracranial traumatic lesions on neuroimaging, witnessed loss of consciousness (LOC), or post-traumatic amnesia (PTA) >1 h. Further, we explored which of the tests in the CENTER-TBI battery might be associated with the largest subacute effects of MTBI (i.e., at 2 weeks post-injury). We recruited 177 patients with MTBI (16-59 years of age) from a regional trauma center and an outpatient clinic,79 trauma control participants, and 81 community control participants. The MTBI group differed from community controls only on one traditional test of processing speed (coding; p = 0.009, Cliff's delta [Δ] = 0.20). Patients with intracranial abnormalities performed worse than those without on a traditional test (phonemic verbal fluency; p = 0.043, Δ= 0.27), and patients with LOC performed differently on the Attention Switching Task from the CANTAB (p = 0.020, Δ=-0.20). Patients with PTA >1 h performed worse than those with <1 h on 10 measures, from traditional tests and the CANTAB (Δ= 0.33-0.20), likely attributable, at least in part, to pre-existing differences in intellectual functioning between groups. In general, those with MTBI had good neuropsychological outcome 2 weeks after injury and no particular CENTER-TBI computerized or traditional tests seemed to be more sensitive to subtle cognitive deficits.
AB - This study investigates subacute cognitive effects of mild traumatic brain injury (MTBI) in the Trondheim Mild TBI Study, as measured, in part, by the neuropsychological test battery of the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) program, including computerized tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and traditional paper-and-pencil tests. We investigated whether cognitive function was associated with injury severity: Intracranial traumatic lesions on neuroimaging, witnessed loss of consciousness (LOC), or post-traumatic amnesia (PTA) >1 h. Further, we explored which of the tests in the CENTER-TBI battery might be associated with the largest subacute effects of MTBI (i.e., at 2 weeks post-injury). We recruited 177 patients with MTBI (16-59 years of age) from a regional trauma center and an outpatient clinic,79 trauma control participants, and 81 community control participants. The MTBI group differed from community controls only on one traditional test of processing speed (coding; p = 0.009, Cliff's delta [Δ] = 0.20). Patients with intracranial abnormalities performed worse than those without on a traditional test (phonemic verbal fluency; p = 0.043, Δ= 0.27), and patients with LOC performed differently on the Attention Switching Task from the CANTAB (p = 0.020, Δ=-0.20). Patients with PTA >1 h performed worse than those with <1 h on 10 measures, from traditional tests and the CANTAB (Δ= 0.33-0.20), likely attributable, at least in part, to pre-existing differences in intellectual functioning between groups. In general, those with MTBI had good neuropsychological outcome 2 weeks after injury and no particular CENTER-TBI computerized or traditional tests seemed to be more sensitive to subtle cognitive deficits.
KW - brain concussion
KW - cognition
KW - neuropsychology
UR - http://www.scopus.com/inward/record.url?scp=85098970849&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85098970849&partnerID=8YFLogxK
U2 - 10.1089/neu.2019.6922
DO - 10.1089/neu.2019.6922
M3 - Article
C2 - 32948095
AN - SCOPUS:85098970849
SN - 0897-7151
VL - 38
SP - 74
EP - 85
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
IS - 1
ER -