Exceptional Survival Among Kentucky Stage IV Non-small Cell Lung Cancer Patients: Appalachian Versus Non-Appalachian Populations

Vira Pravosud; Nathan L. Vanderford; Bin Huang; Thomas C. Tucker; Susanne M. Arnold

doi:10.1111/jrh.12537

Exceptional Survival Among Kentucky Stage IV Non-small Cell Lung Cancer Patients: Appalachian Versus Non-Appalachian Populations

Vira Pravosud, Nathan L. Vanderford, Bin Huang, Thomas C. Tucker, Susanne M. Arnold

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To determine differences in exceptional survival (ES)—survival of 5 years or more past diagnosis—between stage IV non-small cell lung cancer (NSCLC) patients residing in the Appalachian versus non-Appalachian regions of Kentucky. Methods: This was a population-based, retrospective case-control study of Kentucky patients, diagnosed with stage IV NSCLC between January 1, 2000, and December 31, 2011. The data were drawn from the Kentucky Cancer Registry. Findings: Findings from the multivariable logistic regression revealed no significant differences in the odds of ES between patients who resided in Appalachian versus non-Appalachian Kentucky. Being female and undergoing surgery only as the first course of treatment were associated with higher odds of ES. Increasing age, unspecified histology, having poorly differentiated or undifferentiated carcinomas, and receiving radiation therapy only as the first course of treatment were associated with decreased odds of ES. Conclusion: Differences in the odds of ES among stage IV NSCLC patients were not related to residence in Appalachian versus non-Appalachian Kentucky. ES was associated with other nongenetic and treatment factors that warrant further investigations.

Original language	English
Pages (from-to)	14-27
Number of pages	14
Journal	Journal of Rural Health
Volume	38
Issue number	1
DOIs	https://doi.org/10.1111/jrh.12537
State	Published - Jan 1 2022

Bibliographical note

Funding Information:
Data used in this manuscript were provided by the Kentucky Cancer Registry, Lexington, KY. The authors thank Dr Quan Chen, a member of the KCR staff, for his help with obtaining the data. The authors would like to thank consultants from the Robert E. Hemenway Writing Center for their assistance in proofreading this manuscript. In addition, Vira P. would like to thank S. Rivera Polanco for support during this project. This study was supported by the Eller & Billings Student Research Award from the University of Kentucky Appalachian Center. Nathan L. Vanderford is supported by the University of Kentucky (UK) Cancer Center Support Grant [NCI P30CA177558], the UK Center for Cancer and Metabolism [NIGMS P20GM121327], and the UK Appalachian Career Training in Oncology Program [NCI R25CA221765].

Publisher Copyright:
© 2020 National Rural Health Association

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jrh.12537

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title = "Exceptional Survival Among Kentucky Stage IV Non-small Cell Lung Cancer Patients: Appalachian Versus Non-Appalachian Populations",

abstract = "Purpose: To determine differences in exceptional survival (ES)—survival of 5 years or more past diagnosis—between stage IV non-small cell lung cancer (NSCLC) patients residing in the Appalachian versus non-Appalachian regions of Kentucky. Methods: This was a population-based, retrospective case-control study of Kentucky patients, diagnosed with stage IV NSCLC between January 1, 2000, and December 31, 2011. The data were drawn from the Kentucky Cancer Registry. Findings: Findings from the multivariable logistic regression revealed no significant differences in the odds of ES between patients who resided in Appalachian versus non-Appalachian Kentucky. Being female and undergoing surgery only as the first course of treatment were associated with higher odds of ES. Increasing age, unspecified histology, having poorly differentiated or undifferentiated carcinomas, and receiving radiation therapy only as the first course of treatment were associated with decreased odds of ES. Conclusion: Differences in the odds of ES among stage IV NSCLC patients were not related to residence in Appalachian versus non-Appalachian Kentucky. ES was associated with other nongenetic and treatment factors that warrant further investigations.",

author = "Vira Pravosud and Vanderford, {Nathan L.} and Bin Huang and Tucker, {Thomas C.} and Arnold, {Susanne M.}",

note = "Funding Information: Data used in this manuscript were provided by the Kentucky Cancer Registry, Lexington, KY. The authors thank Dr Quan Chen, a member of the KCR staff, for his help with obtaining the data. The authors would like to thank consultants from the Robert E. Hemenway Writing Center for their assistance in proofreading this manuscript. In addition, Vira P. would like to thank S. Rivera Polanco for support during this project. This study was supported by the Eller & Billings Student Research Award from the University of Kentucky Appalachian Center. Nathan L. Vanderford is supported by the University of Kentucky (UK) Cancer Center Support Grant [NCI P30CA177558], the UK Center for Cancer and Metabolism [NIGMS P20GM121327], and the UK Appalachian Career Training in Oncology Program [NCI R25CA221765]. Publisher Copyright: {\textcopyright} 2020 National Rural Health Association",

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AU - Tucker, Thomas C.

AU - Arnold, Susanne M.

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N2 - Purpose: To determine differences in exceptional survival (ES)—survival of 5 years or more past diagnosis—between stage IV non-small cell lung cancer (NSCLC) patients residing in the Appalachian versus non-Appalachian regions of Kentucky. Methods: This was a population-based, retrospective case-control study of Kentucky patients, diagnosed with stage IV NSCLC between January 1, 2000, and December 31, 2011. The data were drawn from the Kentucky Cancer Registry. Findings: Findings from the multivariable logistic regression revealed no significant differences in the odds of ES between patients who resided in Appalachian versus non-Appalachian Kentucky. Being female and undergoing surgery only as the first course of treatment were associated with higher odds of ES. Increasing age, unspecified histology, having poorly differentiated or undifferentiated carcinomas, and receiving radiation therapy only as the first course of treatment were associated with decreased odds of ES. Conclusion: Differences in the odds of ES among stage IV NSCLC patients were not related to residence in Appalachian versus non-Appalachian Kentucky. ES was associated with other nongenetic and treatment factors that warrant further investigations.

AB - Purpose: To determine differences in exceptional survival (ES)—survival of 5 years or more past diagnosis—between stage IV non-small cell lung cancer (NSCLC) patients residing in the Appalachian versus non-Appalachian regions of Kentucky. Methods: This was a population-based, retrospective case-control study of Kentucky patients, diagnosed with stage IV NSCLC between January 1, 2000, and December 31, 2011. The data were drawn from the Kentucky Cancer Registry. Findings: Findings from the multivariable logistic regression revealed no significant differences in the odds of ES between patients who resided in Appalachian versus non-Appalachian Kentucky. Being female and undergoing surgery only as the first course of treatment were associated with higher odds of ES. Increasing age, unspecified histology, having poorly differentiated or undifferentiated carcinomas, and receiving radiation therapy only as the first course of treatment were associated with decreased odds of ES. Conclusion: Differences in the odds of ES among stage IV NSCLC patients were not related to residence in Appalachian versus non-Appalachian Kentucky. ES was associated with other nongenetic and treatment factors that warrant further investigations.

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Exceptional Survival Among Kentucky Stage IV Non-small Cell Lung Cancer Patients: Appalachian Versus Non-Appalachian Populations

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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