Purpose: To determine differences in exceptional survival (ES)—survival of 5 years or more past diagnosis—between stage IV non-small cell lung cancer (NSCLC) patients residing in the Appalachian versus non-Appalachian regions of Kentucky. Methods: This was a population-based, retrospective case-control study of Kentucky patients, diagnosed with stage IV NSCLC between January 1, 2000, and December 31, 2011. The data were drawn from the Kentucky Cancer Registry. Findings: Findings from the multivariable logistic regression revealed no significant differences in the odds of ES between patients who resided in Appalachian versus non-Appalachian Kentucky. Being female and undergoing surgery only as the first course of treatment were associated with higher odds of ES. Increasing age, unspecified histology, having poorly differentiated or undifferentiated carcinomas, and receiving radiation therapy only as the first course of treatment were associated with decreased odds of ES. Conclusion: Differences in the odds of ES among stage IV NSCLC patients were not related to residence in Appalachian versus non-Appalachian Kentucky. ES was associated with other nongenetic and treatment factors that warrant further investigations.
|Number of pages||14|
|Journal||Journal of Rural Health|
|State||Published - Jan 1 2022|
Bibliographical noteFunding Information:
Data used in this manuscript were provided by the Kentucky Cancer Registry, Lexington, KY. The authors thank Dr Quan Chen, a member of the KCR staff, for his help with obtaining the data. The authors would like to thank consultants from the Robert E. Hemenway Writing Center for their assistance in proofreading this manuscript. In addition, Vira P. would like to thank S. Rivera Polanco for support during this project. This study was supported by the Eller & Billings Student Research Award from the University of Kentucky Appalachian Center. Nathan L. Vanderford is supported by the University of Kentucky (UK) Cancer Center Support Grant [NCI P30CA177558], the UK Center for Cancer and Metabolism [NIGMS P20GM121327], and the UK Appalachian Career Training in Oncology Program [NCI R25CA221765].
© 2020 National Rural Health Association
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health