Excessive discounting of delayed reinforcers as a trans-disease process contributing to addiction and other disease-related vulnerabilities: Emerging evidence

Warren K. Bickel, David P. Jarmolowicz, E. Terry Mueller, Mikhail N. Koffarnus, Kirstin M. Gatchalian

Research output: Contribution to journalReview articlepeer-review

471 Scopus citations

Abstract

Delay discounting describes the devaluation of a reinforcer as a function of the delay until its receipt. Although all people discount delayed reinforcers, one consistent finding is that substance-dependent individuals tend to discount delayed reinforcers more rapidly than do healthy controls. Moreover, these higher-than-normal discounting rates have been observed in individuals with other behavioral maladies such as pathological gambling, poor health behavior, and overeating. This suggests that high rates of delay discounting may be a trans-disease process (i.e., a process that occurs across a range of disorders, making findings from one disorder relevant to other disorders). In this paper, we argue that delay discounting is a trans-disease process, undergirded by an imbalance between two competing neurobehavioral decision systems. Implications for our understanding of, and treatment for, this trans-disease process are discussed.

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalPharmacology and Therapeutics
Volume134
Issue number3
DOIs
StatePublished - Jun 2012

Bibliographical note

Funding Information:
This work was supported by NIDA grants R01DA030241 ; R01DA024080 ; R01DA012997 ; and [NIAAA] R01DA024080-02S1 . The authors would like to thank Patsy Marshall for her assistance in manuscript preparation.

Funding

This work was supported by NIDA grants R01DA030241 ; R01DA024080 ; R01DA012997 ; and [NIAAA] R01DA024080-02S1 . The authors would like to thank Patsy Marshall for her assistance in manuscript preparation.

FundersFunder number
National Institute on Drug AbuseR01DA024080, R01DA030241, R01DA012997, T32DA022981
National Institute on Alcohol Abuse and Alcoholism

    Keywords

    • Addiction
    • Delay discounting
    • Gambling
    • Health behaviors
    • Neuroscience
    • Obesity
    • Trans-disease process

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

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