Exclusion of class III malocclusion candidate loci in Brazilian families

R. M. Cruz, J. K. Hartsfield, G. Falcão-Alencar, D. L. Koller, R. W. Pereira, J. Mah, I. Ferrari, S. F. Oliveira

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The role played by genetic components in the etiology of the Class III phenotype, a class of dental malocclusion, is not yet understood. Regions that may be related to the development of Class III malocclusion have been suggested previously. The aim of this study was to search for genetic linkage with 6 microsatellite markers (D1S234, D4S3038, D6S1689, D7S503, D10S1483, and D19S566), near previously proposed candidate regions for Class III. We performed a two-point parametric linkage analysis for 42 affected individuals from 10 Brazilian families with a positive Class III malocclusion segregation. Analysis of our data indicated that there was no evidence for linkage of any of the 6 microsatellite markers to a Class III locus at θ = zero, with data supporting exclusion for 5 of the 6 markers evaluated. The present work reinforces that Class III is likely to demonstrate locus heterogeneity, and there is a dependency of the genetic background of the population in linkage studies.

Original languageEnglish
Pages (from-to)1202-1205
Number of pages4
JournalJournal of Dental Research
Issue number10
StatePublished - Oct 2011

Bibliographical note

Funding Information:
We also thank the University of Brasilia (UnB), Catholic University of Brasília (UCB), and Indiana University for financial support; and Luciana Rollemberg Nogueira for laboratory support. This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sector.


  • Class III malocclusion
  • candidate loci
  • genetic heterogeneity
  • linkage analysis
  • mandibular prognathism
  • microsatellite markers

ASJC Scopus subject areas

  • Dentistry (all)


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