Exercise in sickle cell anemia: Effect on inflammatory and vasoactive mediators

P. Barbeau, K. F. Woods, L. T. Ramsey, M. S. Litaker, D. M. Pollock, J. S. Pollock, L. A. Callahan, A. Kutlar, G. A. Mensah, B. Gutin

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The aim of this study was to determine the response of inflammatory and vasoactive mediators to 3 consecutive days of exercise in African-American women with and without sickle cell anemia (SCA). Circulating inflammatory mediators [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFα)] were measured before, and vasoactive mediators [endothelin-1 (ET-1), nitric oxide metabolites (NOx)] before and after each exercise bout in ten subjects with SCA and ten controls. Exercise did not affect ET-1, IL-6 or CRP concentrations (p>.05). TNFα was higher in SCA than controls (p≤.0005) at all times; however, the response pattern was similar for the groups: no change from day 1 to day 2, but a decrease from day 2 to day 3 (p≤.05). NOx increased significantly after exercise (p≤.0001) but returned to baseline by 24 h afterward. On the 3rd day, NOx increased after exercise in SCA but not in the controls (p≤.05). In conclusion, exercise did not cause a harmful inflammatory response in these individuals with SCA. However, NOx increased after exercise on all 3 days in SCA but appeared attenuated after 2 days in controls.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalEndothelium: Journal of Endothelial Cell Research
Issue number2
StatePublished - 2001

Bibliographical note

Funding Information:
This was study was supported by NIH HD 3.5063.


  • C-reactive protein
  • Endothelin-1
  • Interleukin-6
  • Nitric oxide
  • TNF-alpha

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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