TY - JOUR
T1 - Exercise in sickle cell anemia
T2 - Effect on inflammatory and vasoactive mediators
AU - Barbeau, P.
AU - Woods, K. F.
AU - Ramsey, L. T.
AU - Litaker, M. S.
AU - Pollock, D. M.
AU - Pollock, J. S.
AU - Callahan, L. A.
AU - Kutlar, A.
AU - Mensah, G. A.
AU - Gutin, B.
N1 - Funding Information:
This was study was supported by NIH HD 3.5063.
PY - 2001
Y1 - 2001
N2 - The aim of this study was to determine the response of inflammatory and vasoactive mediators to 3 consecutive days of exercise in African-American women with and without sickle cell anemia (SCA). Circulating inflammatory mediators [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFα)] were measured before, and vasoactive mediators [endothelin-1 (ET-1), nitric oxide metabolites (NOx)] before and after each exercise bout in ten subjects with SCA and ten controls. Exercise did not affect ET-1, IL-6 or CRP concentrations (p>.05). TNFα was higher in SCA than controls (p≤.0005) at all times; however, the response pattern was similar for the groups: no change from day 1 to day 2, but a decrease from day 2 to day 3 (p≤.05). NOx increased significantly after exercise (p≤.0001) but returned to baseline by 24 h afterward. On the 3rd day, NOx increased after exercise in SCA but not in the controls (p≤.05). In conclusion, exercise did not cause a harmful inflammatory response in these individuals with SCA. However, NOx increased after exercise on all 3 days in SCA but appeared attenuated after 2 days in controls.
AB - The aim of this study was to determine the response of inflammatory and vasoactive mediators to 3 consecutive days of exercise in African-American women with and without sickle cell anemia (SCA). Circulating inflammatory mediators [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFα)] were measured before, and vasoactive mediators [endothelin-1 (ET-1), nitric oxide metabolites (NOx)] before and after each exercise bout in ten subjects with SCA and ten controls. Exercise did not affect ET-1, IL-6 or CRP concentrations (p>.05). TNFα was higher in SCA than controls (p≤.0005) at all times; however, the response pattern was similar for the groups: no change from day 1 to day 2, but a decrease from day 2 to day 3 (p≤.05). NOx increased significantly after exercise (p≤.0001) but returned to baseline by 24 h afterward. On the 3rd day, NOx increased after exercise in SCA but not in the controls (p≤.05). In conclusion, exercise did not cause a harmful inflammatory response in these individuals with SCA. However, NOx increased after exercise on all 3 days in SCA but appeared attenuated after 2 days in controls.
KW - C-reactive protein
KW - Endothelin-1
KW - Interleukin-6
KW - Nitric oxide
KW - TNF-alpha
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U2 - 10.3109/10623320109165323
DO - 10.3109/10623320109165323
M3 - Article
C2 - 11572476
AN - SCOPUS:0034838557
SN - 1062-3329
VL - 8
SP - 147
EP - 155
JO - Endothelium: Journal of Endothelial Cell Research
JF - Endothelium: Journal of Endothelial Cell Research
IS - 2
ER -