TY - JOUR
T1 - Expanding the pyrimidine diphosphosugar repertoire
T2 - The chemoenzymatic synthesis of amino- and acetamidoglucopyranosyl derivatives
AU - Jiang, Jiqing
AU - Biggins, John B.
AU - Thorson, Jon S.
PY - 2001/4/17
Y1 - 2001/4/17
N2 - The exploitation of a unique thymidylyltransferase (E p) allows the rapid syntheses of thymidine and uridine 5′-(aminodeoxy-α-D-hexopyranosyl diphosphates), 5′(acetamidodeoxy-α-D-hexopyranosyl diphosphates), and even 5′-(aminodideoxy-α-D-hexopyranosyl diphosphates), which are amino analogues of the products from the native reaction of E p (see scheme).
AB - The exploitation of a unique thymidylyltransferase (E p) allows the rapid syntheses of thymidine and uridine 5′-(aminodeoxy-α-D-hexopyranosyl diphosphates), 5′(acetamidodeoxy-α-D-hexopyranosyl diphosphates), and even 5′-(aminodideoxy-α-D-hexopyranosyl diphosphates), which are amino analogues of the products from the native reaction of E p (see scheme).
KW - Enzyme catalysis
KW - Glycosyl phosphate
KW - Nucleotides
KW - Synthetic methods
KW - Transferases
UR - http://www.scopus.com/inward/record.url?scp=0035901648&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035901648&partnerID=8YFLogxK
U2 - 10.1002/1521-3773(20010417)40:8<1502::AID-ANIE1502>3.0.CO;2-K
DO - 10.1002/1521-3773(20010417)40:8<1502::AID-ANIE1502>3.0.CO;2-K
M3 - Article
AN - SCOPUS:0035901648
SN - 1433-7851
VL - 40
SP - 1502
EP - 1505
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 8
ER -