Background: Ethnic discrimination is frequently experienced among U.S. Latinx communities, and is linked to CVD risk factors, such as depression. Genetic variants may influence this relationship. Objectives: The objectives of this study were to examine associations between experiences of discrimination, rs4680 genotype, and depressive symptoms in Latinx adults. Methods: We analyzed data from 124 Latinx adults with two or more CVD risk factors, and conducted hierarchical linear regression, adjusting for sex, age, income, education, and acculturation. Results: Participants were predominately female (74.2%) and aged 40.2 ± 9.3 years. More experiences of discrimination were associated with higher depressive symptoms (p = 0.041). Those with Met-Met-and Val-Met-genotypes had increased depressive symptoms than those with Val-Val-genotype (p = 0.049). Rs4680 was not a moderator. Conclusion: Findings suggest discrimination and rs4680 genotype are associated with depressive symptoms in Latinx adults, which may increase CVD risk. Further research is needed to better understand biological mechanisms of these relationships.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalHeart and Lung
StatePublished - Sep 1 2022

Bibliographical note

Funding Information:
This work was supported by the NIH/National Institutes of Nursing and the Office of Behavioral and Social Science [Research Grant 1R01NR016262]; DREAM Scholars Predoctoral Fellowship Program, University of Kentucky College of Nursing and the Center for Clinical and Translational Science, National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health [Grant UL1TR001998]; The University of Kentucky College of Nursing Dissertation Award.

Publisher Copyright:
© 2022 Elsevier Inc.


  • COMT
  • Cardiovascular disease
  • Depression
  • Discrimination
  • Latinx

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease'. Together they form a unique fingerprint.

Cite this