Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease

Kaitlin Voigts Key; Steven Estus; Terry A. Lennie; Ana Maria Linares; Gia Mudd-Martin

doi:10.1016/j.hrtlng.2022.04.012

Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease

Kaitlin Voigts Key, Steven Estus, Terry A. Lennie, Ana Maria Linares, Gia Mudd-Martin

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Ethnic discrimination is frequently experienced among U.S. Latinx communities, and is linked to CVD risk factors, such as depression. Genetic variants may influence this relationship. Objectives: The objectives of this study were to examine associations between experiences of discrimination, rs4680 genotype, and depressive symptoms in Latinx adults. Methods: We analyzed data from 124 Latinx adults with two or more CVD risk factors, and conducted hierarchical linear regression, adjusting for sex, age, income, education, and acculturation. Results: Participants were predominately female (74.2%) and aged 40.2 ± 9.3 years. More experiences of discrimination were associated with higher depressive symptoms (p = 0.041). Those with Met-Met-and Val-Met-genotypes had increased depressive symptoms than those with Val-Val-genotype (p = 0.049). Rs4680 was not a moderator. Conclusion: Findings suggest discrimination and rs4680 genotype are associated with depressive symptoms in Latinx adults, which may increase CVD risk. Further research is needed to better understand biological mechanisms of these relationships.

Original language	English
Pages (from-to)	77-81
Number of pages	5
Journal	Heart and Lung
Volume	55
DOIs	https://doi.org/10.1016/j.hrtlng.2022.04.012
State	Published - Sep 1 2022

Bibliographical note

Funding Information:
This work was supported by the NIH/National Institutes of Nursing and the Office of Behavioral and Social Science [Research Grant 1R01NR016262]; DREAM Scholars Predoctoral Fellowship Program, University of Kentucky College of Nursing and the Center for Clinical and Translational Science, National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health [Grant UL1TR001998]; The University of Kentucky College of Nursing Dissertation Award.

Publisher Copyright:
© 2022 Elsevier Inc.

Keywords

COMT
Cardiovascular disease
Depression
Discrimination
Latinx

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.hrtlng.2022.04.012

Cite this

@article{948bf6499af24d708d719342770ef970,

title = "Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease",

abstract = "Background: Ethnic discrimination is frequently experienced among U.S. Latinx communities, and is linked to CVD risk factors, such as depression. Genetic variants may influence this relationship. Objectives: The objectives of this study were to examine associations between experiences of discrimination, rs4680 genotype, and depressive symptoms in Latinx adults. Methods: We analyzed data from 124 Latinx adults with two or more CVD risk factors, and conducted hierarchical linear regression, adjusting for sex, age, income, education, and acculturation. Results: Participants were predominately female (74.2%) and aged 40.2 ± 9.3 years. More experiences of discrimination were associated with higher depressive symptoms (p = 0.041). Those with Met-Met-and Val-Met-genotypes had increased depressive symptoms than those with Val-Val-genotype (p = 0.049). Rs4680 was not a moderator. Conclusion: Findings suggest discrimination and rs4680 genotype are associated with depressive symptoms in Latinx adults, which may increase CVD risk. Further research is needed to better understand biological mechanisms of these relationships.",

keywords = "COMT, Cardiovascular disease, Depression, Discrimination, Latinx",

author = "Key, {Kaitlin Voigts} and Steven Estus and Lennie, {Terry A.} and Linares, {Ana Maria} and Gia Mudd-Martin",

note = "Funding Information: This work was supported by the NIH/National Institutes of Nursing and the Office of Behavioral and Social Science [Research Grant 1R01NR016262]; DREAM Scholars Predoctoral Fellowship Program, University of Kentucky College of Nursing and the Center for Clinical and Translational Science, National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health [Grant UL1TR001998]; The University of Kentucky College of Nursing Dissertation Award. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = sep,

day = "1",

doi = "10.1016/j.hrtlng.2022.04.012",

language = "English",

volume = "55",

pages = "77--81",

}

TY - JOUR

T1 - Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease

AU - Key, Kaitlin Voigts

AU - Estus, Steven

AU - Lennie, Terry A.

AU - Linares, Ana Maria

AU - Mudd-Martin, Gia

N1 - Funding Information: This work was supported by the NIH/National Institutes of Nursing and the Office of Behavioral and Social Science [Research Grant 1R01NR016262]; DREAM Scholars Predoctoral Fellowship Program, University of Kentucky College of Nursing and the Center for Clinical and Translational Science, National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health [Grant UL1TR001998]; The University of Kentucky College of Nursing Dissertation Award. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Background: Ethnic discrimination is frequently experienced among U.S. Latinx communities, and is linked to CVD risk factors, such as depression. Genetic variants may influence this relationship. Objectives: The objectives of this study were to examine associations between experiences of discrimination, rs4680 genotype, and depressive symptoms in Latinx adults. Methods: We analyzed data from 124 Latinx adults with two or more CVD risk factors, and conducted hierarchical linear regression, adjusting for sex, age, income, education, and acculturation. Results: Participants were predominately female (74.2%) and aged 40.2 ± 9.3 years. More experiences of discrimination were associated with higher depressive symptoms (p = 0.041). Those with Met-Met-and Val-Met-genotypes had increased depressive symptoms than those with Val-Val-genotype (p = 0.049). Rs4680 was not a moderator. Conclusion: Findings suggest discrimination and rs4680 genotype are associated with depressive symptoms in Latinx adults, which may increase CVD risk. Further research is needed to better understand biological mechanisms of these relationships.

AB - Background: Ethnic discrimination is frequently experienced among U.S. Latinx communities, and is linked to CVD risk factors, such as depression. Genetic variants may influence this relationship. Objectives: The objectives of this study were to examine associations between experiences of discrimination, rs4680 genotype, and depressive symptoms in Latinx adults. Methods: We analyzed data from 124 Latinx adults with two or more CVD risk factors, and conducted hierarchical linear regression, adjusting for sex, age, income, education, and acculturation. Results: Participants were predominately female (74.2%) and aged 40.2 ± 9.3 years. More experiences of discrimination were associated with higher depressive symptoms (p = 0.041). Those with Met-Met-and Val-Met-genotypes had increased depressive symptoms than those with Val-Val-genotype (p = 0.049). Rs4680 was not a moderator. Conclusion: Findings suggest discrimination and rs4680 genotype are associated with depressive symptoms in Latinx adults, which may increase CVD risk. Further research is needed to better understand biological mechanisms of these relationships.

KW - COMT

KW - Cardiovascular disease

KW - Depression

KW - Discrimination

KW - Latinx

UR - http://www.scopus.com/inward/record.url?scp=85129315299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85129315299&partnerID=8YFLogxK

U2 - 10.1016/j.hrtlng.2022.04.012

DO - 10.1016/j.hrtlng.2022.04.012

M3 - Article

C2 - 35490661

AN - SCOPUS:85129315299

SN - 0147-9563

VL - 55

SP - 77

EP - 81

JO - Heart and Lung

JF - Heart and Lung

ER -

Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this