Experimental diffuse colitis in cats: Observations on motor changes

The colitis model elicited by this modified acetic acid ulcer technique produces a reliable diffuse lesion in the appropriate location in 100% of the cats treated. Although of chemical origin, the histopathology of these lesions does share a number of characteristics with inflammatory colonic diseases, such as ulcerative, granulomatous, and necrotizing colitis. The motility alterations recorded in cats afflicted with these lesions demonstrate a pattern similar to that observed in individuals with ulcerative colitis and/or other diarrheal states. The suppression of Urecholine-stimulated activity during the period of severest diarrhea, hence ulceration, is not characteristic of that reported in patients with colitis and may indicate some temporary impairment in nervous organization. The opposite is observed during the period of healing and regeneration of the mucosa in these animals where the colonic motility is observed to be greatly increased, perhaps reflecting an increased sensitivity.