Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents

William Marciel de Souza; Alex Martins Machado; Luiz Tadeu Moraes Figueiredo

doi:10.1590/0074-02760160021

Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents

William Marciel de Souza, Alex Martins Machado, Luiz Tadeu Moraes Figueiredo

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This study shows an experimental spillover infection of Sigmodontinae rodents with Rio Mamore hantavirus (RIOMV). Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.

Original language	English
Pages (from-to)	399-402
Number of pages	4
Journal	Memorias do Instituto Oswaldo Cruz
Volume	111
Issue number	6
DOIs	https://doi.org/10.1590/0074-02760160021
State	Published - Jun 2016

Bibliographical note

Publisher Copyright:
© 2016, Fundacao Oswaldo Cruz. All rights reserved.

Keywords

Experimental infection
Rio Mamore hantavirus
Wild Sigmodontinae rodents

ASJC Scopus subject areas

Microbiology (medical)

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10.1590/0074-02760160021

Cite this

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abstract = "This study shows an experimental spillover infection of Sigmodontinae rodents with Rio Mamore hantavirus (RIOMV). Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.",

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AB - This study shows an experimental spillover infection of Sigmodontinae rodents with Rio Mamore hantavirus (RIOMV). Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.

KW - Experimental infection

KW - Rio Mamore hantavirus

KW - Wild Sigmodontinae rodents

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Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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