Experimental production of diffuse colitis in rats

B. R. MacPherson, C. J. Pfeiffer

Research output: Contribution to journalArticlepeer-review

269 Scopus citations


Diffuse, topical application of dilute acetic acid to the serosal surface of rat colon, of standardized intraluminal (per rectum) instillation induced a reproducible, diffuse colitis in a dose-response manner. These lesions were reproduced with 100% reliability and were evaluated up to 60 days when healing occurred. Histopathological features of this chemically induced colitis were diffuse ulceration of the distal colon, occurrence of pseudopolyp-like structures, alterations in crypt depth and mucus secretion, and a transmural, nonspecific inflammatory response.

Original languageEnglish
Pages (from-to)135-150
Number of pages16
Issue number2
StatePublished - 1978

ASJC Scopus subject areas

  • Gastroenterology


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