Exploring cancer metabolism using Stable isotope-resolved metabolomics (SIRM)

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76 Scopus citations


Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMRand mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.

Original languageEnglish
Pages (from-to)11601-11609
Number of pages9
JournalJournal of Biological Chemistry
Issue number28
StatePublished - Jul 14 2017

Bibliographical note

Funding Information:
This work was supported in part by National Institutes of Health Grants T32CA165990 (to R. C. B.), 1R01ES022191-01 (to T. W. M. F. and R. M. H.), and 1P01CA163223-01A1 (to A. N. L. and T. W. M. F.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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