Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability

John L. Fowlkes; Margaret K. Winkler

doi:10.1016/S1359-6101(02)00005-9

Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability

John L. Fowlkes, Margaret K. Winkler

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Abstract

Metallo-proteinases are implicated in many processes involved in tissue remodeling, cell motility, morphogenesis, and cell and organ growth and differentiation. Recent data suggest that several members of the metzincin family including the matrix metallo-proteinases (MMPs), adamalysin-related proteinases, and the newly described pappalysins, are intimately involved in the activation and/or release of cytokines and growth factors. We review how metzincins, working through unique mechanisms, influence the extracellular milieu of several important cytokines and growth factors including transforming growth factor-β (TGF-β), TNF-α, IGFs and HB-epidermal growth factor (EGF). Because metzincins can modulate the bioavailability of these peptides, they may serve as unique target molecules to control cytokine and growth factor action in the extracellular environment.

Original language	English
Pages (from-to)	277-287
Number of pages	11
Journal	Cytokine and Growth Factor Reviews
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/S1359-6101(02)00005-9
State	Published - 2002

Bibliographical note

Funding Information:
This work was supported partially through a grant from the National Institutes of Health (R01-DK055653 to JLF) and through a grant from the American Lung Association (CG-002-N to MKW).

Funding

This work was supported partially through a grant from the National Institutes of Health (R01-DK055653 to JLF) and through a grant from the American Lung Association (CG-002-N to MKW).

Funders	Funder number
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases	R01DK055653
National Institute of Diabetes and Digestive and Kidney Diseases
American Lung Association	CG-002-N
American Lung Association

Keywords

Adamalysins
Cytokine
Growth factor
Matrix metallo-proteinase
Metzincin

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S1359-6101(02)00005-9

Cite this

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title = "Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability",

abstract = "Metallo-proteinases are implicated in many processes involved in tissue remodeling, cell motility, morphogenesis, and cell and organ growth and differentiation. Recent data suggest that several members of the metzincin family including the matrix metallo-proteinases (MMPs), adamalysin-related proteinases, and the newly described pappalysins, are intimately involved in the activation and/or release of cytokines and growth factors. We review how metzincins, working through unique mechanisms, influence the extracellular milieu of several important cytokines and growth factors including transforming growth factor-β (TGF-β), TNF-α, IGFs and HB-epidermal growth factor (EGF). Because metzincins can modulate the bioavailability of these peptides, they may serve as unique target molecules to control cytokine and growth factor action in the extracellular environment.",

keywords = "Adamalysins, Cytokine, Growth factor, Matrix metallo-proteinase, Metzincin",

author = "Fowlkes, {John L.} and Winkler, {Margaret K.}",

note = "Funding Information: This work was supported partially through a grant from the National Institutes of Health (R01-DK055653 to JLF) and through a grant from the American Lung Association (CG-002-N to MKW).",

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doi = "10.1016/S1359-6101(02)00005-9",

language = "English",

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AU - Fowlkes, John L.

AU - Winkler, Margaret K.

N1 - Funding Information: This work was supported partially through a grant from the National Institutes of Health (R01-DK055653 to JLF) and through a grant from the American Lung Association (CG-002-N to MKW).

PY - 2002

Y1 - 2002

N2 - Metallo-proteinases are implicated in many processes involved in tissue remodeling, cell motility, morphogenesis, and cell and organ growth and differentiation. Recent data suggest that several members of the metzincin family including the matrix metallo-proteinases (MMPs), adamalysin-related proteinases, and the newly described pappalysins, are intimately involved in the activation and/or release of cytokines and growth factors. We review how metzincins, working through unique mechanisms, influence the extracellular milieu of several important cytokines and growth factors including transforming growth factor-β (TGF-β), TNF-α, IGFs and HB-epidermal growth factor (EGF). Because metzincins can modulate the bioavailability of these peptides, they may serve as unique target molecules to control cytokine and growth factor action in the extracellular environment.

AB - Metallo-proteinases are implicated in many processes involved in tissue remodeling, cell motility, morphogenesis, and cell and organ growth and differentiation. Recent data suggest that several members of the metzincin family including the matrix metallo-proteinases (MMPs), adamalysin-related proteinases, and the newly described pappalysins, are intimately involved in the activation and/or release of cytokines and growth factors. We review how metzincins, working through unique mechanisms, influence the extracellular milieu of several important cytokines and growth factors including transforming growth factor-β (TGF-β), TNF-α, IGFs and HB-epidermal growth factor (EGF). Because metzincins can modulate the bioavailability of these peptides, they may serve as unique target molecules to control cytokine and growth factor action in the extracellular environment.

KW - Adamalysins

KW - Cytokine

KW - Growth factor

KW - Matrix metallo-proteinase

KW - Metzincin

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DO - 10.1016/S1359-6101(02)00005-9

M3 - Review article

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SN - 1359-6101

VL - 13

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JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 3

ER -

Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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