Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability

John L. Fowlkes, Margaret K. Winkler

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


Metallo-proteinases are implicated in many processes involved in tissue remodeling, cell motility, morphogenesis, and cell and organ growth and differentiation. Recent data suggest that several members of the metzincin family including the matrix metallo-proteinases (MMPs), adamalysin-related proteinases, and the newly described pappalysins, are intimately involved in the activation and/or release of cytokines and growth factors. We review how metzincins, working through unique mechanisms, influence the extracellular milieu of several important cytokines and growth factors including transforming growth factor-β (TGF-β), TNF-α, IGFs and HB-epidermal growth factor (EGF). Because metzincins can modulate the bioavailability of these peptides, they may serve as unique target molecules to control cytokine and growth factor action in the extracellular environment.

Original languageEnglish
Pages (from-to)277-287
Number of pages11
JournalCytokine and Growth Factor Reviews
Issue number3
StatePublished - 2002

Bibliographical note

Funding Information:
This work was supported partially through a grant from the National Institutes of Health (R01-DK055653 to JLF) and through a grant from the American Lung Association (CG-002-N to MKW).


  • Adamalysins
  • Cytokine
  • Growth factor
  • Matrix metallo-proteinase
  • Metzincin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • General Biochemistry, Genetics and Molecular Biology


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