Expressed gene sequences of the equine cytokines interleukin-17 and interleukin-23

Dannielle Tompkins, Edward Hudgens, David Horohov, Cynthia L. Baldwin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


This report describes the initial cloning and characterization of the equine interleukin-17 (IL-17) expressed gene sequence from mRNA obtained from equine intestinal tissue and interleukin-23 (IL-23) expressed gene sequence from mRNA obtained from equine peripheral blood mononuclear cells. Equine IL-17 has 462 nucleotides in the translated region, determined by homology with known human and mouse sequences, and shares 84% and 75% identity, respectively. For the deduced amino acid sequences, the identity with human and mouse is 76% and 70%. Equine IL-23 has 579 nucleotides in the translated region. Homology with known human and mouse sequences was determined to be 89% and 77%. Deduced amino acid identities are 89% with the human sequence and 70% with the mouse sequence. The gene sequences were identified as part of the U.S. Veterinary Immune Reagent Network with a goal of developing reagents in order to aid veterinary researchers in the investigation of diseases in livestock species.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalVeterinary Immunology and Immunopathology
Issue number2-4
StatePublished - Feb 15 2010

Bibliographical note

Funding Information:
We thank John Loftus for technical assistance with the preparation of cells. Funding for this work was provided by NRI-USDA competitive grants program grant # 2006-35204-16880 for the “US Veterinary Immune Reagent Network” ( ).


  • Cytokines
  • Equine
  • IL-17
  • IL-23
  • T cells
  • Th17
  • Th2

ASJC Scopus subject areas

  • Immunology
  • General Veterinary


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