@article{a03f281f7b03457da1df344a76741b3d,
title = "Expression of morphine-conditioned hyperactivity is attenuated by naloxone and pimozide",
abstract = "The present experiments assessed whether morphine-conditioned hyperactivity could be attenuated by either the opiate antagonist naloxone or the dopamine antagonist pimozide. Both of these antagonists were shown to block the unconditioned hyperactivity induced by 2 mg/kg morphine (Experiment 1). Rats were then conditioned by pairing this dose of morphine repeatedly with a distinctive environment (Experiment 2). Following several drug-environment pairings, rats displayed a hyperactive conditioned response (CR) when exposed to the environment in the absence of the drug. CR expression was counteracted by 1 mg/kg naloxone and was attenuated by pimozide (0.25, 0.33, and 0.4 mg/kg) in a dose-related manner. These findings suggest that the unconditioned and conditioned hyperactive responses produced by morphine may involve similar neuropharmacologic substrates.",
keywords = "Classical conditioning, Conditioned hyperactivity, Morphine, Naloxone, Pimozide",
author = "Neisewander, {J. L.} and Bardo, {M. T.}",
year = "1987",
month = nov,
doi = "10.1007/BF00187249",
language = "English",
volume = "93",
pages = "314--319",
number = "3",
}