TY - JOUR
T1 - Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse
AU - Goldstein, L. B.
AU - Vitek, M. P.
AU - Dawson, H.
AU - Bullman, S.
PY - 2000/8/23
Y1 - 2000/8/23
N2 - Motor recovery after unilateral sensorimotor cortex ablation or sham- injury was measured in apolipoprotein E knockout and wild-type mice by testing their abilities to traverse a narrow beam. All mice trained without difficulty. Sham-operated mice performed perfectly regardless of genotype throughout testing. There was no difference in motor scores between lesioned apolipoprotein E knockout and wild-type mice on a first trial 24 h after injury (P > 0.05). There was a significant overall effect of lesion on motor performance (two-way repeated measures analysis of variance F1,42 = 304, P < 0.0001), a significant time effect (F17,714 = 58, P < 0.0001) and a lesion by time interaction (F17,714 = 58, P < 0.0001). However, there was no effect of apolipoprotein E genotype group on recovery rate (i.e. there was no lesion group by genotype group by time interaction, F17,714 = 0.33, P = 1.00) and no effect of genotype on the final level of motor performance 12 days after the lesion (Kruskal-Wallis H = 5.79, P = 0.12). These data suggest that motor recovery after unilateral injury to the sensorimotor cortex does not vary with apolipoprotein E genotype. (C) 2000 IBRO.
AB - Motor recovery after unilateral sensorimotor cortex ablation or sham- injury was measured in apolipoprotein E knockout and wild-type mice by testing their abilities to traverse a narrow beam. All mice trained without difficulty. Sham-operated mice performed perfectly regardless of genotype throughout testing. There was no difference in motor scores between lesioned apolipoprotein E knockout and wild-type mice on a first trial 24 h after injury (P > 0.05). There was a significant overall effect of lesion on motor performance (two-way repeated measures analysis of variance F1,42 = 304, P < 0.0001), a significant time effect (F17,714 = 58, P < 0.0001) and a lesion by time interaction (F17,714 = 58, P < 0.0001). However, there was no effect of apolipoprotein E genotype group on recovery rate (i.e. there was no lesion group by genotype group by time interaction, F17,714 = 0.33, P = 1.00) and no effect of genotype on the final level of motor performance 12 days after the lesion (Kruskal-Wallis H = 5.79, P = 0.12). These data suggest that motor recovery after unilateral injury to the sensorimotor cortex does not vary with apolipoprotein E genotype. (C) 2000 IBRO.
KW - Knockout mice
KW - Locomotion
KW - Motor cortex
KW - Recovery
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U2 - 10.1016/S0306-4522(00)00234-7
DO - 10.1016/S0306-4522(00)00234-7
M3 - Article
C2 - 10974433
AN - SCOPUS:0034706056
SN - 0306-4522
VL - 99
SP - 705
EP - 710
JO - Neuroscience
JF - Neuroscience
IS - 4
ER -