Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse

L. B. Goldstein, M. P. Vitek, H. Dawson, S. Bullman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Motor recovery after unilateral sensorimotor cortex ablation or sham- injury was measured in apolipoprotein E knockout and wild-type mice by testing their abilities to traverse a narrow beam. All mice trained without difficulty. Sham-operated mice performed perfectly regardless of genotype throughout testing. There was no difference in motor scores between lesioned apolipoprotein E knockout and wild-type mice on a first trial 24 h after injury (P > 0.05). There was a significant overall effect of lesion on motor performance (two-way repeated measures analysis of variance F1,42 = 304, P < 0.0001), a significant time effect (F17,714 = 58, P < 0.0001) and a lesion by time interaction (F17,714 = 58, P < 0.0001). However, there was no effect of apolipoprotein E genotype group on recovery rate (i.e. there was no lesion group by genotype group by time interaction, F17,714 = 0.33, P = 1.00) and no effect of genotype on the final level of motor performance 12 days after the lesion (Kruskal-Wallis H = 5.79, P = 0.12). These data suggest that motor recovery after unilateral injury to the sensorimotor cortex does not vary with apolipoprotein E genotype. (C) 2000 IBRO.

Original languageEnglish
Pages (from-to)705-710
Number of pages6
JournalNeuroscience
Volume99
Issue number4
DOIs
StatePublished - Aug 23 2000

Keywords

  • Knockout mice
  • Locomotion
  • Motor cortex
  • Recovery

ASJC Scopus subject areas

  • General Neuroscience

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