Abstract
Purpose: To compare the expression of pregnane xenobiotic receptor and certain multi-drug resistance proteins in retinoblastoma. Methods: Using tissue microarray analyses, we studied 62 pathology specimens for expression of pregnane xenobiotic receptor, multi-drug resistance 1/P glycoprotein, multi-drug resistance proteins 1, 2, and 4, and breast cancer resistant protein. Results: Comparing tumors treated with primary enucleation with tumors treated with chemotherapy and/or radiation showed no significant differences in the expression of multi-drug resistance proteins or pregnane xenobiotic receptor. Pregnane xenobiotic receptor was correlated with multi-drug resistance protein 2 expression (p 0.001). Conclusion: Our results indicate selection, rather than induction, of chemoresistant cells as a cause for treatment failure in managing retinoblastoma with primary systemic chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 386-394 |
| Number of pages | 9 |
| Journal | Current Eye Research |
| Volume | 34 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2009 |
Bibliographical note
Funding Information:This study was supported by grants to Matthew W. Wilson from Research to Prevent Blindness, Inc., New York, NY, and the St. Giles Foundation, New York, NY.
Keywords
- Chemotherapy
- MRP-1/P-glycoprotein
- Multi-drug resistance
- Pregnane X receptor
- Retinoblastoma
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
