Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma

Matthew W. Wilson, Charles H. Fraga, Carlos Rodriguez-Galindo, Nikolas Hagedorn, Markos L. Leggas, Clinton Stewart

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Purpose: To compare the expression of pregnane xenobiotic receptor and certain multi-drug resistance proteins in retinoblastoma. Methods: Using tissue microarray analyses, we studied 62 pathology specimens for expression of pregnane xenobiotic receptor, multi-drug resistance 1/P glycoprotein, multi-drug resistance proteins 1, 2, and 4, and breast cancer resistant protein. Results: Comparing tumors treated with primary enucleation with tumors treated with chemotherapy and/or radiation showed no significant differences in the expression of multi-drug resistance proteins or pregnane xenobiotic receptor. Pregnane xenobiotic receptor was correlated with multi-drug resistance protein 2 expression (p 0.001). Conclusion: Our results indicate selection, rather than induction, of chemoresistant cells as a cause for treatment failure in managing retinoblastoma with primary systemic chemotherapy.

Original languageEnglish
Pages (from-to)386-394
Number of pages9
JournalCurrent Eye Research
Issue number5
StatePublished - May 2009

Bibliographical note

Funding Information:
This study was supported by grants to Matthew W. Wilson from Research to Prevent Blindness, Inc., New York, NY, and the St. Giles Foundation, New York, NY.


  • Chemotherapy
  • MRP-1/P-glycoprotein
  • Multi-drug resistance
  • Pregnane X receptor
  • Retinoblastoma

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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