Abstract
Purpose: To compare the expression of pregnane xenobiotic receptor and certain multi-drug resistance proteins in retinoblastoma. Methods: Using tissue microarray analyses, we studied 62 pathology specimens for expression of pregnane xenobiotic receptor, multi-drug resistance 1/P glycoprotein, multi-drug resistance proteins 1, 2, and 4, and breast cancer resistant protein. Results: Comparing tumors treated with primary enucleation with tumors treated with chemotherapy and/or radiation showed no significant differences in the expression of multi-drug resistance proteins or pregnane xenobiotic receptor. Pregnane xenobiotic receptor was correlated with multi-drug resistance protein 2 expression (p 0.001). Conclusion: Our results indicate selection, rather than induction, of chemoresistant cells as a cause for treatment failure in managing retinoblastoma with primary systemic chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 386-394 |
| Number of pages | 9 |
| Journal | Current Eye Research |
| Volume | 34 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2009 |
Bibliographical note
Funding Information:This study was supported by grants to Matthew W. Wilson from Research to Prevent Blindness, Inc., New York, NY, and the St. Giles Foundation, New York, NY.
Funding
This study was supported by grants to Matthew W. Wilson from Research to Prevent Blindness, Inc., New York, NY, and the St. Giles Foundation, New York, NY.
| Funders | Funder number |
|---|---|
| Research to Prevent Blindness | |
| St. Giles Foundation |
Keywords
- Chemotherapy
- MRP-1/P-glycoprotein
- Multi-drug resistance
- Pregnane X receptor
- Retinoblastoma
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
