Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma

Matthew W. Wilson; Charles H. Fraga; Carlos Rodriguez-Galindo; Nikolas Hagedorn; Markos L. Leggas; Clinton Stewart

doi:10.1080/02713680902859621

Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma

Matthew W. Wilson
, Charles H. Fraga
, Carlos Rodriguez-Galindo
, Nikolas Hagedorn
, Markos L. Leggas
, Clinton Stewart

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Purpose: To compare the expression of pregnane xenobiotic receptor and certain multi-drug resistance proteins in retinoblastoma. Methods: Using tissue microarray analyses, we studied 62 pathology specimens for expression of pregnane xenobiotic receptor, multi-drug resistance 1/P glycoprotein, multi-drug resistance proteins 1, 2, and 4, and breast cancer resistant protein. Results: Comparing tumors treated with primary enucleation with tumors treated with chemotherapy and/or radiation showed no significant differences in the expression of multi-drug resistance proteins or pregnane xenobiotic receptor. Pregnane xenobiotic receptor was correlated with multi-drug resistance protein 2 expression (p 0.001). Conclusion: Our results indicate selection, rather than induction, of chemoresistant cells as a cause for treatment failure in managing retinoblastoma with primary systemic chemotherapy.

Original language	English
Pages (from-to)	386-394
Number of pages	9
Journal	Current Eye Research
Volume	34
Issue number	5
DOIs	https://doi.org/10.1080/02713680902859621
State	Published - May 2009

Bibliographical note

Funding Information:
This study was supported by grants to Matthew W. Wilson from Research to Prevent Blindness, Inc., New York, NY, and the St. Giles Foundation, New York, NY.

Funding

This study was supported by grants to Matthew W. Wilson from Research to Prevent Blindness, Inc., New York, NY, and the St. Giles Foundation, New York, NY.

Funders
Research to Prevent Blindness
St. Giles Foundation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chemotherapy
MRP-1/P-glycoprotein
Multi-drug resistance
Pregnane X receptor
Retinoblastoma

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Access to Document

10.1080/02713680902859621

Cite this

@article{72212a654950488fa08bf1943e9105b2,

title = "Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma",

abstract = "Purpose: To compare the expression of pregnane xenobiotic receptor and certain multi-drug resistance proteins in retinoblastoma. Methods: Using tissue microarray analyses, we studied 62 pathology specimens for expression of pregnane xenobiotic receptor, multi-drug resistance 1/P glycoprotein, multi-drug resistance proteins 1, 2, and 4, and breast cancer resistant protein. Results: Comparing tumors treated with primary enucleation with tumors treated with chemotherapy and/or radiation showed no significant differences in the expression of multi-drug resistance proteins or pregnane xenobiotic receptor. Pregnane xenobiotic receptor was correlated with multi-drug resistance protein 2 expression (p 0.001). Conclusion: Our results indicate selection, rather than induction, of chemoresistant cells as a cause for treatment failure in managing retinoblastoma with primary systemic chemotherapy.",

keywords = "Chemotherapy, MRP-1/P-glycoprotein, Multi-drug resistance, Pregnane X receptor, Retinoblastoma",

author = "Wilson, \{Matthew W.\} and Fraga, \{Charles H.\} and Carlos Rodriguez-Galindo and Nikolas Hagedorn and Leggas, \{Markos L.\} and Clinton Stewart",

note = "Funding Information: This study was supported by grants to Matthew W. Wilson from Research to Prevent Blindness, Inc., New York, NY, and the St. Giles Foundation, New York, NY.",

year = "2009",

month = may,

doi = "10.1080/02713680902859621",

language = "English",

volume = "34",

pages = "386--394",

number = "5",

}

TY - JOUR

T1 - Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma

AU - Wilson, Matthew W.

AU - Fraga, Charles H.

AU - Rodriguez-Galindo, Carlos

AU - Hagedorn, Nikolas

AU - Leggas, Markos L.

AU - Stewart, Clinton

N1 - Funding Information: This study was supported by grants to Matthew W. Wilson from Research to Prevent Blindness, Inc., New York, NY, and the St. Giles Foundation, New York, NY.

PY - 2009/5

Y1 - 2009/5

N2 - Purpose: To compare the expression of pregnane xenobiotic receptor and certain multi-drug resistance proteins in retinoblastoma. Methods: Using tissue microarray analyses, we studied 62 pathology specimens for expression of pregnane xenobiotic receptor, multi-drug resistance 1/P glycoprotein, multi-drug resistance proteins 1, 2, and 4, and breast cancer resistant protein. Results: Comparing tumors treated with primary enucleation with tumors treated with chemotherapy and/or radiation showed no significant differences in the expression of multi-drug resistance proteins or pregnane xenobiotic receptor. Pregnane xenobiotic receptor was correlated with multi-drug resistance protein 2 expression (p 0.001). Conclusion: Our results indicate selection, rather than induction, of chemoresistant cells as a cause for treatment failure in managing retinoblastoma with primary systemic chemotherapy.

AB - Purpose: To compare the expression of pregnane xenobiotic receptor and certain multi-drug resistance proteins in retinoblastoma. Methods: Using tissue microarray analyses, we studied 62 pathology specimens for expression of pregnane xenobiotic receptor, multi-drug resistance 1/P glycoprotein, multi-drug resistance proteins 1, 2, and 4, and breast cancer resistant protein. Results: Comparing tumors treated with primary enucleation with tumors treated with chemotherapy and/or radiation showed no significant differences in the expression of multi-drug resistance proteins or pregnane xenobiotic receptor. Pregnane xenobiotic receptor was correlated with multi-drug resistance protein 2 expression (p 0.001). Conclusion: Our results indicate selection, rather than induction, of chemoresistant cells as a cause for treatment failure in managing retinoblastoma with primary systemic chemotherapy.

KW - Chemotherapy

KW - MRP-1/P-glycoprotein

KW - Multi-drug resistance

KW - Pregnane X receptor

KW - Retinoblastoma

UR - https://www.scopus.com/pages/publications/67649649882

UR - https://www.scopus.com/pages/publications/67649649882#tab=citedBy

U2 - 10.1080/02713680902859621

DO - 10.1080/02713680902859621

M3 - Article

C2 - 19401882

AN - SCOPUS:67649649882

SN - 0271-3683

VL - 34

SP - 386

EP - 394

JO - Current Eye Research

JF - Current Eye Research

IS - 5

ER -

Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this