Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord

Subhra Prakash Hui, James R. Monaghan, S. Randal Voss, Sukla Ghosh

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background: The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration. Results: Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells. Conclusions: These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls. Developmental Dynamics 242:847-860, 2013.

Original languageEnglish
Pages (from-to)847-860
Number of pages14
JournalDevelopmental Dynamics
Issue number7
StatePublished - Jul 2013


  • Axolotl
  • Myelin associated glycoprotein (MAG)
  • Nogo receptor (NgR)
  • Nogo-A
  • Regeneration
  • Spinal cord injury (SCI)

ASJC Scopus subject areas

  • Developmental Biology


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