TY - JOUR
T1 - Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord
AU - Hui, Subhra Prakash
AU - Monaghan, James R.
AU - Voss, S. Randal
AU - Ghosh, Sukla
PY - 2013/7
Y1 - 2013/7
N2 - Background: The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration. Results: Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells. Conclusions: These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls. Developmental Dynamics 242:847-860, 2013.
AB - Background: The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration. Results: Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells. Conclusions: These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls. Developmental Dynamics 242:847-860, 2013.
KW - Axolotl
KW - Myelin associated glycoprotein (MAG)
KW - Nogo receptor (NgR)
KW - Nogo-A
KW - Regeneration
KW - Spinal cord injury (SCI)
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U2 - 10.1002/dvdy.23976
DO - 10.1002/dvdy.23976
M3 - Article
C2 - 23592243
AN - SCOPUS:84879295053
SN - 1058-8388
VL - 242
SP - 847
EP - 860
JO - Developmental Dynamics
JF - Developmental Dynamics
IS - 7
ER -