Expression profiles of 10 circadian clock genes in human peripheral blood mononuclear cells

Hiroaki Kusanagi, Akiko Hida, Kohtoku Satoh, Masaru Echizenya, Tetsuo Shimizu, Julie S. Pendergast, Shin Yamazaki, Kazuo Mishima

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


The circadian clock system regulates daily rhythms of physiology and behavior. The mammalian master clock in the suprachiasmatic nuclei orchestrates these biological rhythms in peripheral tissues. Since blood is the most accessible tissue source, we sought to dissect the human circadian clock system by characterizing clock gene expression in human peripheral blood mononuclear cells (PBMCs) isolated from eight young, healthy subjects. By evaluating the temporal expression profiles of 10 circadian clock genes, we found that Period 1 (Per1), Per2, and Per3 are rhythmically expressed in human blood samples. Our results suggest that evaluating the rhythmic expression of human Per genes could reveal an individual's circadian phenotype.

Original languageEnglish
Pages (from-to)136-142
Number of pages7
JournalNeuroscience Research
Issue number2
StatePublished - Jun 2008

Bibliographical note

Funding Information:
This study was supported by Special Coordination Funds of the Ministry of Education, Culture, Sports, and Technology of Japan, and by a Grant-in-Aid for Cooperative Research from the Ministry of Health, Labour, and Welfare of Japan.


  • Circadian
  • Clock genes
  • Expression profiles
  • Human peripheral blood mononuclear cells (PBMCs)
  • Period (Per)

ASJC Scopus subject areas

  • General Neuroscience


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