Extended longitudinal analysis of arterial pressure and heart rate control in unanesthetized rats with type 1 diabetes

Chikodi N. Anigbogu, Richard O. Speakman, Dennis L. Silcox, Laura V. Brown, David R. Brown, Ming C. Gong, Abhijit R. Patwardhan, L. Raymond Reynolds, Dennis G. Karounos, Don E. Burgess, Bobby R. Baldridge, David C. Randall

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We recorded arterial pressure (BP) and heart rate (HR) in type-1 diabetic rats vs. controls for > 6. months. Diabetic rats (DIAB) were maintained on insulin from the day glucose >250. mg/dl ("Day 0"). Weight was similar between groups until ~. 3. weeks before Day 0 when the weight in DIAB transiently lagged the controls (CONT); this difference was maintained throughout the study, but both groups otherwise gained weight in parallel. Plasma glucose attained 371 ± 109 (SD) mg/dl by day 1 in DIAB. Mean BP was similar across groups, and declined through the initial 4-6. months in both the CONT (at -0.06 ± 0.04. mm. Hg/day) and in the DIAB (at -0.14 ± 0.21. mm. Hg/day; NS vs. CONT). HR in the CONT (Month 1: 341 ± 13. bpm) exceeded DIAB (325 ± 25. bpm) through ~. 6. months after Day 0, and also decreased progressively over this period in CONT (-0.19 ± 0.14. bpm/day) and DIAB (-0.29 ± 0.23. bpm/day; NS vs. CONT) before leveling. The BP power within 0.35-0.45. Hz changed during the 90. min before vs. after the transition from dark to light, and light to dark; there were no between group differences. The slope of the log-log linear portion of the BP power spectrum between 1.0/h and 1/min was similar across groups, and increased in both from month 1 to month 6. Regulatory mechanisms maintain similar profiles in BP and HR in diabetic vs. control animals through the initial half year of the disease.

Original languageEnglish
Pages (from-to)20-29
Number of pages10
JournalAutonomic Neuroscience: Basic and Clinical
Issue number1-2
StatePublished - Sep 25 2012

Bibliographical note

Funding Information:
Supported by grant RO1 NS39774 , RO1 HL082791 and P20 RR021954 from the National Institutes of Health . We gratefully acknowledge the assistance of Kevin Donohue, Ph.D., Data Beam Professor, Department of Electrical and Computer Engineering, College of Engineering, University of Kentucky, for his help in evaluating data and writing this manuscript.


  • Autonomic nervous system
  • Cardiovascular system
  • Dysautonomia
  • Plasma glucose
  • Slope β (beta)
  • Weight gain

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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