Abstract
Recent clinical trials have documented the use of extended-release (ER) opioids in the management of chronic non-malignant pain. This manuscript reviews the clinical pharmacology of investigational and current marketed ER opioids. Recent randomised clinical trials of ER opioids that document the efficacy and safety of opioid therapy for chronic pain are reviewed. Finally, the abuse liability of ER opioids is discussed. Current technologies aimed at defeating the abuse of ER opioids will also be presented.
| Original language | English |
|---|---|
| Pages (from-to) | 489-497 |
| Number of pages | 9 |
| Journal | Expert Opinion on Drug Delivery |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2006 |
Bibliographical note
Copyright:Copyright 2009 Elsevier B.V., All rights reserved.
Keywords
- Abuse deterrence
- Chronic pain
- Extended release
- Neuropathic pain
- Opioids
- Sustained release
ASJC Scopus subject areas
- Pharmaceutical Science