Extended-release opioids for the management of chronic non-malignant pain

Paul Sloan, Najib Babul

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


Recent clinical trials have documented the use of extended-release (ER) opioids in the management of chronic non-malignant pain. This manuscript reviews the clinical pharmacology of investigational and current marketed ER opioids. Recent randomised clinical trials of ER opioids that document the efficacy and safety of opioid therapy for chronic pain are reviewed. Finally, the abuse liability of ER opioids is discussed. Current technologies aimed at defeating the abuse of ER opioids will also be presented.

Original languageEnglish
Pages (from-to)489-497
Number of pages9
JournalExpert Opinion on Drug Delivery
Issue number4
StatePublished - Jul 2006

Bibliographical note

Copyright 2009 Elsevier B.V., All rights reserved.


  • Abuse deterrence
  • Chronic pain
  • Extended release
  • Neuropathic pain
  • Opioids
  • Sustained release

ASJC Scopus subject areas

  • Pharmaceutical Science


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