Extended-spectrum β-lactamases: Epidemiology, detection, and treatment

S. Nathisuwan, D. S. Burgess, J. S. Lewis

Research output: Contribution to journalReview articlepeer-review

142 Scopus citations

Abstract

Extended-spectrum β-lactamases (ESBLs) are extremely broad spectrum β-lactamase enzymes found in a variety of Enterobacteriaceae. Most strains producing these β-lactamases are Klebsiella pneumoniae, other Klebsiella species (i.e., K. oxytoca), and Escherichia coli. When producing these enzymes, organisms become highly effective at inactivating various β-lactam antibiotics. In addition, ESBL-producing bacteria are frequently resistant to many classes of antibiotics, resulting in difficult-to-treat infections. Other problems due to ESBL-producing bacteria are difficulty in detecting the presence of ESBLs, limited treatment options, and deleterious impact on clinical outcomes. Clinicians should be familiar with the clinical significance of these enzymes and potential strategies for dealing with this growing problem.

Original languageEnglish
Pages (from-to)920-928
Number of pages9
JournalPharmacotherapy
Volume21
Issue number8
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Pharmacology (medical)

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