TY - JOUR
T1 - Extended use dexamethasone-associated posterior reversible encephalopathy syndrome with cisplatin-based chemotherapy
AU - Nguyen, My Chau T.
AU - Virk, Irim Y.
AU - Chew, Lita
AU - Villano, J. Lee
PY - 2009/12
Y1 - 2009/12
N2 - We describe a normotensive patient who developed posterior reversible encephalopathy syndrome following prolonged use of dexamethasone for nausea control with cisplatin and pemetrexed chemotherapy. A 32-year-old woman with advanced intraperitoneal mesothelioma developed new-onset seizures and cognitive impairment. MRI of the brain demonstrated several areas of increased signal on T2-weighted and fluid-attenuated inversion recovery sequences within the subcortical white matter of both hemispheres. Chemotherapy was discontinued and dexamethasone tapered-off. She returned to her baseline with resolution of MRI abnormalities. We hypothesize that extended use of dexamethasone potentiated the relatively uncommon complication of leukotoxicity associated with cisplatin, and we elaborate on dexamethasone's contribution.
AB - We describe a normotensive patient who developed posterior reversible encephalopathy syndrome following prolonged use of dexamethasone for nausea control with cisplatin and pemetrexed chemotherapy. A 32-year-old woman with advanced intraperitoneal mesothelioma developed new-onset seizures and cognitive impairment. MRI of the brain demonstrated several areas of increased signal on T2-weighted and fluid-attenuated inversion recovery sequences within the subcortical white matter of both hemispheres. Chemotherapy was discontinued and dexamethasone tapered-off. She returned to her baseline with resolution of MRI abnormalities. We hypothesize that extended use of dexamethasone potentiated the relatively uncommon complication of leukotoxicity associated with cisplatin, and we elaborate on dexamethasone's contribution.
KW - Cisplatin
KW - Dexamethasone
KW - Encephalopathy
KW - Posterior reversible encephalopathy syndrome (PRES)
UR - http://www.scopus.com/inward/record.url?scp=70350714230&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350714230&partnerID=8YFLogxK
U2 - 10.1016/j.jocn.2009.05.012
DO - 10.1016/j.jocn.2009.05.012
M3 - Article
C2 - 19800799
AN - SCOPUS:70350714230
SN - 0967-5868
VL - 16
SP - 1688
EP - 1690
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 12
ER -