Extended use dexamethasone-associated posterior reversible encephalopathy syndrome with cisplatin-based chemotherapy

My Chau T. Nguyen, Irim Y. Virk, Lita Chew, J. Lee Villano

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We describe a normotensive patient who developed posterior reversible encephalopathy syndrome following prolonged use of dexamethasone for nausea control with cisplatin and pemetrexed chemotherapy. A 32-year-old woman with advanced intraperitoneal mesothelioma developed new-onset seizures and cognitive impairment. MRI of the brain demonstrated several areas of increased signal on T2-weighted and fluid-attenuated inversion recovery sequences within the subcortical white matter of both hemispheres. Chemotherapy was discontinued and dexamethasone tapered-off. She returned to her baseline with resolution of MRI abnormalities. We hypothesize that extended use of dexamethasone potentiated the relatively uncommon complication of leukotoxicity associated with cisplatin, and we elaborate on dexamethasone's contribution.

Original languageEnglish
Pages (from-to)1688-1690
Number of pages3
JournalJournal of Clinical Neuroscience
Volume16
Issue number12
DOIs
StatePublished - Dec 2009

Keywords

  • Cisplatin
  • Dexamethasone
  • Encephalopathy
  • Posterior reversible encephalopathy syndrome (PRES)

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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