Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice

Hisham Qosa, Loqman A. Mohamed, Yazan S. Batarseh, Saeed Alqahtani, Baher Ibrahim, Harry LeVine, Jeffrey N. Keller, Amal Kaddoumi

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Extra-virgin olive oil (EVOO) is one of the main elements of Mediterranean diet. Several studies have suggested that EVOO has several health promoting effects that could protect from and decrease the risk of Alzheimer's disease (AD). In this study, we investigated the effect of consumption of EVOO-enriched diet on amyloid- and tau-related pathological alterations that are associated with the progression of AD and cerebral amyloid angiopathy (CAA) in TgSwDI mice. Feeding mice with EVOO-enriched diet for 6. months, beginning at an age before amyloid-β (Aβ) accumulation starts, has significantly reduced total Aβ and tau brain levels with a significant improvement in mouse cognitive behavior. This reduction in brain Aβ was explained by the enhanced Aβ clearance pathways and reduced brain production of Aβ via modulation of amyloid-β precursor protein processing. On the other hand, although feeding mice with EVOO-enriched diet for 3. months, beginning at an age after Aβ accumulation starts, showed improved clearance across the blood-brain barrier and significant reduction in Aβ levels, it did not affect tau levels or improve cognitive functions of TgSwDI mouse. Collectively, results of this study suggest that the long-term consumption of EVOO-containing diet starting at early age provides a protective effect against AD and its related disorder CAA.

Original languageEnglish
Pages (from-to)1479-1490
Number of pages12
JournalJournal of Nutritional Biochemistry
Issue number12
StatePublished - Dec 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc..


  • Amyloid-β
  • Blood-brain barrier
  • Clearance
  • Extra-virgin olive oil
  • Tau

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry


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