Abstract
Extracellular vesicles (EVs) are emerging mediators of intracellular and inter-organ communications in cardiovascular diseases (CVDs), especially in the pathogenesis of heart failure through the transference of EV-containing bioactive substances. microRNAs (miRNAs) are contained in EV cargo and are involved in the progression of heart failure. Over the past several years, a growing body of evidence has suggested that the biogenesis of miRNAs and EVs is tightly regulated, and the sorting of miRNAs into EVs is highly selective and tightly controlled. Extracellular miRNAs, particularly circulating EV-miRNAs, have shown promising potential as prognostic and diagnostic biomarkers for heart failure and as therapeutic targets. In this review, we summarize the latest progress concerning the role of EV-miRNAs in HF and their application in a therapeutic strategy development for heart failure.
| Original language | English |
|---|---|
| Article number | 2145 |
| Journal | Cells |
| Volume | 12 |
| Issue number | 17 |
| DOIs | |
| State | Published - Sep 2023 |
Bibliographical note
Publisher Copyright:© 2023 by the authors.
Funding
This work was supported by the National Institution of Health Grant R01HL153176 to IHZ/CT; American Heart Association (AHA) Career Development Award (19CDA34520004) to C.T.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | R01HL153176 |
| American the American Heart Association | 19CDA34520004 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- biomarkers
- extracellular vesicles
- heart failure
- microRNAs
- sorting mechanism
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
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