Extraction of cortical modularity patterns for neural prosthetics

Sam A. Deadwyler, Ioan Opris, Lucas M. Santos, Robert E. Hampson, Greg A. Gerhardt, Dong Song, Vasilis Z. Marmarelis, Theodore W. Berger

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Cortical modularity is a fundamental microanatomic feature of the brain with direct implications for the cognitive function of cortical microcircuits. Neural activity recorded simultaneously with multi-electrode arrays (MEAs) from supra- and infra-granular layers along adjacent cortical minicolumns in PFC was shown to extract microanatomic codes relevant for successful behavioral performance. In addition, it is shown that pharmacologic agents disrupt the micro-anatomic processing and cognitive performance, but that recovery from cognitive impairment is produced by application of a cognitive prosthesis, via nonlinear multi-input multi-output (MIMO) model stimulation of microanatomic outputs with successful MIMO codes. The functional basis of this approach provides the potential for applying cognitive prostheses to a broad range of neurological and psychiatric dysfunctions involving cortical processes.

Original languageEnglish
Title of host publicationRecent Advances On The Modular Organization Of The Cortex
Number of pages18
ISBN (Electronic)9789401799003
StatePublished - Jan 1 2015

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media Dordrecht 2015.


  • Brain machine interface
  • Cortical layer
  • Cortical microcircuits
  • Cortical minicolumn
  • Microelectode arrays
  • Prosthetics
  • Recording

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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