Extraocular muscles: Extraocular muscle metabolism

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

A defining characteristic of the extraocular muscles is their fast and constant activity. To sustain it, energy demands by the contractile apparatus must be met by energy supply pathways. We have just begun to outline major differences in the relative importance of some pathways, such as the use of lactate for aerobic metabolism, loss of creatine kinase as an ATP buffering system, and the use of mitochondria as calcium sinks. More importantly, there is now concrete evidence demonstrating divergence in mitochondrial composition and function between extraocular and prototypical skeletal muscles. These differences are likely to influence the contractile function of the extraocular muscles and may determine their preferential involvement in some congenital and age-related mitochondrial myopathies.

Original languageEnglish
Title of host publicationEncyclopedia of the Eye
Pages105-110
Number of pages6
ISBN (Electronic)9780123742032
DOIs
StatePublished - Jan 1 2010

Bibliographical note

Publisher Copyright:
© 2010 Elsevier Ltd. All rights reserved.

Keywords

  • Adenine nucleotide translocator
  • Calcium
  • Creatine kinase
  • Cytoskeleton
  • Electron transport chain
  • Energetics
  • Extraocular muscles
  • Gene expression profiling
  • Glycolysis
  • Lactate
  • M line
  • Metabolism
  • Mitochondria
  • Oxidative phosphorylation
  • Phosphocreatine

ASJC Scopus subject areas

  • General Medicine

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