TY - JOUR
T1 - Extreme insulin resistance
T2 - Indications and approaches to the use of U-500 insulin in type 2 diabetes mellitus
AU - Dailey, Alexandria M.
AU - Tannock, Lisa R.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/4
Y1 - 2011/4
N2 - The use of U-500 insulin in the management of highly insulin resistant diabetic patients is growing. There are a number of reports that have noted the effects of U-500 insulin using multiple daily injections or continuous subcutaneous insulin infusion on hemoglobin A1c, weight, and total daily insulin dosage. The effect of U-500 insulin use on glycemic control, changes in body weight, total daily insulin dosage, incidence of hypoglycemia, and effect on lipid levels and blood pressure as well as patient satisfaction and quality of life will be reviewed. In addition, this article will delineate algorithms of U-500 use, compare multiple daily injections or continuous subcutaneous insulin infusion, and discuss U-500 insulin pharmacokinetics.
AB - The use of U-500 insulin in the management of highly insulin resistant diabetic patients is growing. There are a number of reports that have noted the effects of U-500 insulin using multiple daily injections or continuous subcutaneous insulin infusion on hemoglobin A1c, weight, and total daily insulin dosage. The effect of U-500 insulin use on glycemic control, changes in body weight, total daily insulin dosage, incidence of hypoglycemia, and effect on lipid levels and blood pressure as well as patient satisfaction and quality of life will be reviewed. In addition, this article will delineate algorithms of U-500 use, compare multiple daily injections or continuous subcutaneous insulin infusion, and discuss U-500 insulin pharmacokinetics.
KW - Hypoglycemia
KW - Insulin efficacy
KW - Insulin resistance
KW - Obesity
KW - Pharmacokinetics
KW - U-500 insulin
UR - http://www.scopus.com/inward/record.url?scp=79955820380&partnerID=8YFLogxK
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U2 - 10.1007/s11892-010-0167-6
DO - 10.1007/s11892-010-0167-6
M3 - Review article
C2 - 21161448
AN - SCOPUS:79955820380
SN - 1534-4827
VL - 11
SP - 77
EP - 82
JO - Current Diabetes Reports
JF - Current Diabetes Reports
IS - 2
ER -