Extubation readiness in preterm infants: Evaluating the role of monitoring intermittent hypoxemia

Elie G. Abu Jawdeh; Amrita Pant; Aayush Gabrani; M. Douglas Cunningham; Thomas M. Raffay; Philip M. Westgate

doi:10.3390/children8030237

Extubation readiness in preterm infants: Evaluating the role of monitoring intermittent hypoxemia

Elie G. Abu Jawdeh, Amrita Pant, Aayush Gabrani, M. Douglas Cunningham, Thomas M. Raffay, Philip M. Westgate

Biostatistics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Preterm infants with respiratory distress may require mechanical ventilation which is associated with increased pulmonary morbidities. Prompt and successful extubation to noninvasive support is a pressing goal. In this communication, we show original data that increased recurring intermittent hypoxemia (IH, oxygen saturation <80%) may be associated with extubation failure at 72 h in a cohort of neonates <30 weeks gestational age. Current-generation bedside high-resolution pulse oximeters provide saturation profiles that may be of use in identifying extubation readiness and failure. A larger prospective study that utilizes intermittent hypoxemia as an adjunct predictor for extubation readiness is warranted.

Original language	English
Article number	237
Journal	Children
Volume	8
Issue number	3
DOIs	https://doi.org/10.3390/children8030237
State	Published - Mar 2021

Bibliographical note

Funding Information:
Funding: The study was funded in part by: (1) The Gerber Foundation (EGA, PI), (2) University of Kentucky’s National Center for Advancing Translational Sciences, UL1RR033173, and (3) TMR is supported by the NIH K08HL133459-04 grant.

Funding Information:
The study was funded in part by: (1) The Gerber Foundation (EGA, PI), (2) University of Kentucky?s National Center for Advancing Translational Sciences, UL1RR033173, and (3) TMR is supported by the NIH K08HL133459-04 grant.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Extubation
Intermittent hypoxemia
Intubation
Preterm
Respiratory distress

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.3390/children8030237

Cite this

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abstract = "Preterm infants with respiratory distress may require mechanical ventilation which is associated with increased pulmonary morbidities. Prompt and successful extubation to noninvasive support is a pressing goal. In this communication, we show original data that increased recurring intermittent hypoxemia (IH, oxygen saturation <80%) may be associated with extubation failure at 72 h in a cohort of neonates <30 weeks gestational age. Current-generation bedside high-resolution pulse oximeters provide saturation profiles that may be of use in identifying extubation readiness and failure. A larger prospective study that utilizes intermittent hypoxemia as an adjunct predictor for extubation readiness is warranted.",

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AU - Cunningham, M. Douglas

AU - Raffay, Thomas M.

AU - Westgate, Philip M.

N1 - Funding Information: Funding: The study was funded in part by: (1) The Gerber Foundation (EGA, PI), (2) University of Kentucky’s National Center for Advancing Translational Sciences, UL1RR033173, and (3) TMR is supported by the NIH K08HL133459-04 grant. Funding Information: The study was funded in part by: (1) The Gerber Foundation (EGA, PI), (2) University of Kentucky?s National Center for Advancing Translational Sciences, UL1RR033173, and (3) TMR is supported by the NIH K08HL133459-04 grant. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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AB - Preterm infants with respiratory distress may require mechanical ventilation which is associated with increased pulmonary morbidities. Prompt and successful extubation to noninvasive support is a pressing goal. In this communication, we show original data that increased recurring intermittent hypoxemia (IH, oxygen saturation <80%) may be associated with extubation failure at 72 h in a cohort of neonates <30 weeks gestational age. Current-generation bedside high-resolution pulse oximeters provide saturation profiles that may be of use in identifying extubation readiness and failure. A larger prospective study that utilizes intermittent hypoxemia as an adjunct predictor for extubation readiness is warranted.

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Extubation readiness in preterm infants: Evaluating the role of monitoring intermittent hypoxemia

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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