Preterm infants with respiratory distress may require mechanical ventilation which is associated with increased pulmonary morbidities. Prompt and successful extubation to noninvasive support is a pressing goal. In this communication, we show original data that increased recurring intermittent hypoxemia (IH, oxygen saturation <80%) may be associated with extubation failure at 72 h in a cohort of neonates <30 weeks gestational age. Current-generation bedside high-resolution pulse oximeters provide saturation profiles that may be of use in identifying extubation readiness and failure. A larger prospective study that utilizes intermittent hypoxemia as an adjunct predictor for extubation readiness is warranted.
|State||Published - Mar 2021|
Bibliographical noteFunding Information:
Funding: The study was funded in part by: (1) The Gerber Foundation (EGA, PI), (2) University of Kentucky’s National Center for Advancing Translational Sciences, UL1RR033173, and (3) TMR is supported by the NIH K08HL133459-04 grant.
The study was funded in part by: (1) The Gerber Foundation (EGA, PI), (2) University of Kentucky?s National Center for Advancing Translational Sciences, UL1RR033173, and (3) TMR is supported by the NIH K08HL133459-04 grant.
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- Intermittent hypoxemia
- Respiratory distress
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health