Factors affecting the antibody immunogenicity of vaccines against sars-cov-2: A focused review

Zhangkai Jason Cheng; Mingshan Xue; Peiyan Zheng; Jiali Lyu; Zhiqing Zhan; Haisheng Hu; Yong Zhang; Xiaohua Douglas Zhang; Baoqing Sun

doi:10.3390/vaccines9080869

Factors affecting the antibody immunogenicity of vaccines against sars-cov-2: A focused review

Zhangkai Jason Cheng, Mingshan Xue, Peiyan Zheng, Jiali Lyu, Zhiqing Zhan, Haisheng Hu, Yong Zhang, Xiaohua Douglas Zhang, Baoqing Sun

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Vaccines are a crucial part of the global anti-pandemic effort against COVID-19. The effects of vaccines, as well as their common influencing factors, are the most important issues that we should focus on at this time. To this end, we review statistics on immunogenicity after vaccination, using neutralizing antibodies as the main reference index. Age, infection history, and virus variants are compared, and vaccination program recommendations are made accordingly. Suggestions are made to address concerns raised by the vaccines’ shortened development cycle, as well as the emergence of immunity escape of viral variants. Finally, a brief description and future prospects are provided based on the principle of the ADE effect and previous experience with similar viruses.

Original language	English
Article number	869
Journal	Vaccines
Volume	9
Issue number	8
DOIs	https://doi.org/10.3390/vaccines9080869
State	Published - Aug 2021

Bibliographical note

Funding Information:
Funding: This project was supported by the Guangzhou Institute of Respiratory Health Open Project (Funds provided by China Evergrande Group) (Project No: 2020GIRHHMS04), and the Zhongnanshan Medical Foundation of Guangdong Province (Project No: ZNSA-2021005 and Project No: ZNSA-2020001).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Keywords

ADE
COVID-19
Neutralizing antibody
Vaccines
Variants

ASJC Scopus subject areas

Immunology
Pharmacology
Drug Discovery
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/vaccines9080869

Cite this

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abstract = "Vaccines are a crucial part of the global anti-pandemic effort against COVID-19. The effects of vaccines, as well as their common influencing factors, are the most important issues that we should focus on at this time. To this end, we review statistics on immunogenicity after vaccination, using neutralizing antibodies as the main reference index. Age, infection history, and virus variants are compared, and vaccination program recommendations are made accordingly. Suggestions are made to address concerns raised by the vaccines{\textquoteright} shortened development cycle, as well as the emergence of immunity escape of viral variants. Finally, a brief description and future prospects are provided based on the principle of the ADE effect and previous experience with similar viruses.",

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note = "Funding Information: Funding: This project was supported by the Guangzhou Institute of Respiratory Health Open Project (Funds provided by China Evergrande Group) (Project No: 2020GIRHHMS04), and the Zhongnanshan Medical Foundation of Guangdong Province (Project No: ZNSA-2021005 and Project No: ZNSA-2020001). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).",

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AU - Zhan, Zhiqing

AU - Hu, Haisheng

AU - Zhang, Yong

AU - Zhang, Xiaohua Douglas

AU - Sun, Baoqing

N1 - Funding Information: Funding: This project was supported by the Guangzhou Institute of Respiratory Health Open Project (Funds provided by China Evergrande Group) (Project No: 2020GIRHHMS04), and the Zhongnanshan Medical Foundation of Guangdong Province (Project No: ZNSA-2021005 and Project No: ZNSA-2020001). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

PY - 2021/8

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N2 - Vaccines are a crucial part of the global anti-pandemic effort against COVID-19. The effects of vaccines, as well as their common influencing factors, are the most important issues that we should focus on at this time. To this end, we review statistics on immunogenicity after vaccination, using neutralizing antibodies as the main reference index. Age, infection history, and virus variants are compared, and vaccination program recommendations are made accordingly. Suggestions are made to address concerns raised by the vaccines’ shortened development cycle, as well as the emergence of immunity escape of viral variants. Finally, a brief description and future prospects are provided based on the principle of the ADE effect and previous experience with similar viruses.

AB - Vaccines are a crucial part of the global anti-pandemic effort against COVID-19. The effects of vaccines, as well as their common influencing factors, are the most important issues that we should focus on at this time. To this end, we review statistics on immunogenicity after vaccination, using neutralizing antibodies as the main reference index. Age, infection history, and virus variants are compared, and vaccination program recommendations are made accordingly. Suggestions are made to address concerns raised by the vaccines’ shortened development cycle, as well as the emergence of immunity escape of viral variants. Finally, a brief description and future prospects are provided based on the principle of the ADE effect and previous experience with similar viruses.

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Factors affecting the antibody immunogenicity of vaccines against sars-cov-2: A focused review

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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