Factors Associated with Interest in Gene-Panel Testing and Risk Communication Preferences in Women from BRCA1/2 Negative Families

Kristina G. Flores; Laurie E. Steffen; Christopher J. McLouth; Belinda E. Vicuña; Amanda Gammon; Wendy Kohlmann; Lucretia Vigil; Zoneddy R. Dayao; Melanie E. Royce; Anita Y. Kinney

doi:10.1007/s10897-016-0001-7

Factors Associated with Interest in Gene-Panel Testing and Risk Communication Preferences in Women from BRCA1/2 Negative Families

Kristina G. Flores, Laurie E. Steffen, Christopher J. McLouth, Belinda E. Vicuña, Amanda Gammon, Wendy Kohlmann, Lucretia Vigil, Zoneddy R. Dayao, Melanie E. Royce, Anita Y. Kinney

Behavioral Science

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Scientific advances have allowed the development of multiplex gene-panels to assess many genes simultaneously in women who have tested negative for BRCA1/2. We examined correlates of interest in testing for genes that confer modest and moderate breast cancer risk and risk communication preferences for women from BRCA negative families. Female first-degree relatives of breast cancer patients who tested negative for BRCA1/2 mutations (N = 149) completed a survey assessing multiplex genetic testing interest and risk communication preferences. Interest in testing was high (70 %) and even higher if results could guide risk-reducing behavior changes such as taking medications (79 %). Participants preferred to receive genomic risk communications from a variety of sources including: primary care physicians (83 %), genetic counselors (78 %), printed materials (71 %) and the web (60 %). Factors that were independently associated with testing interest were: perceived lifetime risk of developing cancer (odds ratio (OR) = 1.67: 95 % confidence interval (CI) 1.06–2.65) and high cancer worry (OR = 3.12: CI 1.28–7.60). Findings suggest that women from BRCA1/2 negative families are a unique population and may be primed for behavior change. Findings also provide guidance for clinicians who can help develop genomic risk communications, promote informed decision making and customize behavioral interventions.

Original language	English
Pages (from-to)	480-490
Number of pages	11
Journal	Journal of Genetic Counseling
Volume	26
Issue number	3
DOIs	https://doi.org/10.1007/s10897-016-0001-7
State	Published - Jun 1 2017

Bibliographical note

Funding Information:
We would like to thank the REACH Project participants and their relatives, who made this research possible. This work was supported by grants from the National Cancer Institute at the National Institutes of Health (1R01CA129142 to AYK and U01 CA152958) and the UNM Comprehensive Cancer Center P30 (P30CA118100). The project was also supported by the Shared Resources (P30 CA042014) at Huntsman Cancer Institute (Biostatistics and Research Design, Genetic Counseling, Research Informatics, and the Utah Population Database [UPDB]); the Utah Cancer Registry, which is funded by Contract No.HHSN261201000026C from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program with additional support from the Utah State Department of Health and the University of Utah; the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant 8UL1TR000105 (formerly UL1RR025764). This content is solely the responsibility of the authors and does not necessarily reflect the opinions or views of the funding and supporting agencies.

Publisher Copyright:
© 2016, National Society of Genetic Counselors, Inc.

Keywords

BRCA1/2 negative
Gene-panel
Genetic testing
Hereditary breast cancer
Informed decision-making

ASJC Scopus subject areas

Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10897-016-0001-7

Cite this

Flores, K. G., Steffen, L. E., McLouth, C. J., Vicuña, B. E., Gammon, A., Kohlmann, W., Vigil, L., Dayao, Z. R., Royce, M. E., & Kinney, A. Y. (2017). Factors Associated with Interest in Gene-Panel Testing and Risk Communication Preferences in Women from BRCA1/2 Negative Families. Journal of Genetic Counseling, 26(3), 480-490. https://doi.org/10.1007/s10897-016-0001-7

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abstract = "Scientific advances have allowed the development of multiplex gene-panels to assess many genes simultaneously in women who have tested negative for BRCA1/2. We examined correlates of interest in testing for genes that confer modest and moderate breast cancer risk and risk communication preferences for women from BRCA negative families. Female first-degree relatives of breast cancer patients who tested negative for BRCA1/2 mutations (N = 149) completed a survey assessing multiplex genetic testing interest and risk communication preferences. Interest in testing was high (70 %) and even higher if results could guide risk-reducing behavior changes such as taking medications (79 %). Participants preferred to receive genomic risk communications from a variety of sources including: primary care physicians (83 %), genetic counselors (78 %), printed materials (71 %) and the web (60 %). Factors that were independently associated with testing interest were: perceived lifetime risk of developing cancer (odds ratio (OR) = 1.67: 95 % confidence interval (CI) 1.06–2.65) and high cancer worry (OR = 3.12: CI 1.28–7.60). Findings suggest that women from BRCA1/2 negative families are a unique population and may be primed for behavior change. Findings also provide guidance for clinicians who can help develop genomic risk communications, promote informed decision making and customize behavioral interventions.",

keywords = "BRCA1/2 negative, Gene-panel, Genetic testing, Hereditary breast cancer, Informed decision-making",

author = "Flores, {Kristina G.} and Steffen, {Laurie E.} and McLouth, {Christopher J.} and Vicu{\~n}a, {Belinda E.} and Amanda Gammon and Wendy Kohlmann and Lucretia Vigil and Dayao, {Zoneddy R.} and Royce, {Melanie E.} and Kinney, {Anita Y.}",

note = "Funding Information: We would like to thank the REACH Project participants and their relatives, who made this research possible. This work was supported by grants from the National Cancer Institute at the National Institutes of Health (1R01CA129142 to AYK and U01 CA152958) and the UNM Comprehensive Cancer Center P30 (P30CA118100). The project was also supported by the Shared Resources (P30 CA042014) at Huntsman Cancer Institute (Biostatistics and Research Design, Genetic Counseling, Research Informatics, and the Utah Population Database [UPDB]); the Utah Cancer Registry, which is funded by Contract No.HHSN261201000026C from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program with additional support from the Utah State Department of Health and the University of Utah; the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant 8UL1TR000105 (formerly UL1RR025764). This content is solely the responsibility of the authors and does not necessarily reflect the opinions or views of the funding and supporting agencies. Publisher Copyright: {\textcopyright} 2016, National Society of Genetic Counselors, Inc.",

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AU - Dayao, Zoneddy R.

AU - Royce, Melanie E.

AU - Kinney, Anita Y.

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Factors Associated with Interest in Gene-Panel Testing and Risk Communication Preferences in Women from BRCA1/2 Negative Families

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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