Failure to detect binding of LcrH to the V antigen of Yersinia pestis

K. A. Fields; A. W. Williams; S. C. Straley

doi:10.1128/iai.65.9.3954-3957.1997

Failure to detect binding of LcrH to the V antigen of Yersinia pestis

K. A. Fields, A. W. Williams, S. C. Straley

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

V antigen of Yersinia pestis has been reported to bind the chaperone LcrH. We were unable to demonstrate this interaction. Despite methodological differences between our study and an earlier study we believe that the previous findings were artifactual. One likely confounding element was the tendency of LcrH to adhere on its own to metal chelation chromatographic resin.

Original language	English
Pages (from-to)	3954-3957
Number of pages	4
Journal	Infection and Immunity
Volume	65
Issue number	9
DOIs	https://doi.org/10.1128/iai.65.9.3954-3957.1997
State	Published - 1997

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/iai.65.9.3954-3957.1997

Cite this

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title = "Failure to detect binding of LcrH to the V antigen of Yersinia pestis",

abstract = "V antigen of Yersinia pestis has been reported to bind the chaperone LcrH. We were unable to demonstrate this interaction. Despite methodological differences between our study and an earlier study we believe that the previous findings were artifactual. One likely confounding element was the tendency of LcrH to adhere on its own to metal chelation chromatographic resin.",

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AU - Fields, K. A.

AU - Williams, A. W.

AU - Straley, S. C.

PY - 1997

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N2 - V antigen of Yersinia pestis has been reported to bind the chaperone LcrH. We were unable to demonstrate this interaction. Despite methodological differences between our study and an earlier study we believe that the previous findings were artifactual. One likely confounding element was the tendency of LcrH to adhere on its own to metal chelation chromatographic resin.

AB - V antigen of Yersinia pestis has been reported to bind the chaperone LcrH. We were unable to demonstrate this interaction. Despite methodological differences between our study and an earlier study we believe that the previous findings were artifactual. One likely confounding element was the tendency of LcrH to adhere on its own to metal chelation chromatographic resin.

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U2 - 10.1128/iai.65.9.3954-3957.1997

DO - 10.1128/iai.65.9.3954-3957.1997

M3 - Article

C2 - 9284179

AN - SCOPUS:0030954706

SN - 0019-9567

VL - 65

SP - 3954

EP - 3957

JO - Infection and Immunity

JF - Infection and Immunity

IS - 9

ER -

Failure to detect binding of LcrH to the V antigen of Yersinia pestis

Abstract

ASJC Scopus subject areas

UN SDGs

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