False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency

Andrew Paul Demidowich; Amartya Kundu; James C. Reynolds; Francesco S. Celi

doi:10.1007/s13139-015-0375-8

False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency

Andrew Paul Demidowich
, Amartya Kundu
, James C. Reynolds
, Francesco S. Celi

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A 42-year-old female with immunoglobulin A deficiency and recurrent sinopulmonary infections underwent thyroidectomy for papillary thyroid cancer (PTC). Follow-up ¹²³I scintigraphy demonstrated diffuse pulmonary uptake, suggesting metastatic disease. However, subsequent pathologic, biochemical and radiographic testing proved that she was in fact disease free, and the initial ¹²³I pulmonary uptake was identified as a false positive. Inflammatory conditions may rarely cause iodine uptake in non-thyroidal tissues due to local retention, organification, and/or immunologic utilization. To avoid exposing patients to unnecessary treatments, it is critical for clinicians to recognize that comorbid pulmonary conditions may mimic metastatic PTC on radioiodine scintigraphy.

Original language	English
Pages (from-to)	270-272
Number of pages	3
Journal	Nuclear Medicine and Molecular Imaging
Volume	50
Issue number	3
DOIs	https://doi.org/10.1007/s13139-015-0375-8
State	Published - Sep 1 2016

Bibliographical note

Publisher Copyright:
© 2015, Korean Society of Nuclear Medicine (outside the USA).

Funding

Andrew Demidowich and Amartya Kundu contributed equally to this work and should be considered co-primary authors. This research was supported by the Division of Intramural Research of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH.

Funders
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

False-positive reactions
IgA deficiency
Papillary thyroid carcinoma
Radionuclide imaging
Scintigraphy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1007/s13139-015-0375-8

Cite this

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title = "False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency",

abstract = "A 42-year-old female with immunoglobulin A deficiency and recurrent sinopulmonary infections underwent thyroidectomy for papillary thyroid cancer (PTC). Follow-up 123I scintigraphy demonstrated diffuse pulmonary uptake, suggesting metastatic disease. However, subsequent pathologic, biochemical and radiographic testing proved that she was in fact disease free, and the initial 123I pulmonary uptake was identified as a false positive. Inflammatory conditions may rarely cause iodine uptake in non-thyroidal tissues due to local retention, organification, and/or immunologic utilization. To avoid exposing patients to unnecessary treatments, it is critical for clinicians to recognize that comorbid pulmonary conditions may mimic metastatic PTC on radioiodine scintigraphy.",

keywords = "False-positive reactions, IgA deficiency, Papillary thyroid carcinoma, Radionuclide imaging, Scintigraphy",

author = "Demidowich, \{Andrew Paul\} and Amartya Kundu and Reynolds, \{James C.\} and Celi, \{Francesco S.\}",

note = "Publisher Copyright: {\textcopyright} 2015, Korean Society of Nuclear Medicine (outside the USA).",

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doi = "10.1007/s13139-015-0375-8",

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T1 - False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency

AU - Demidowich, Andrew Paul

AU - Kundu, Amartya

AU - Reynolds, James C.

AU - Celi, Francesco S.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - A 42-year-old female with immunoglobulin A deficiency and recurrent sinopulmonary infections underwent thyroidectomy for papillary thyroid cancer (PTC). Follow-up 123I scintigraphy demonstrated diffuse pulmonary uptake, suggesting metastatic disease. However, subsequent pathologic, biochemical and radiographic testing proved that she was in fact disease free, and the initial 123I pulmonary uptake was identified as a false positive. Inflammatory conditions may rarely cause iodine uptake in non-thyroidal tissues due to local retention, organification, and/or immunologic utilization. To avoid exposing patients to unnecessary treatments, it is critical for clinicians to recognize that comorbid pulmonary conditions may mimic metastatic PTC on radioiodine scintigraphy.

AB - A 42-year-old female with immunoglobulin A deficiency and recurrent sinopulmonary infections underwent thyroidectomy for papillary thyroid cancer (PTC). Follow-up 123I scintigraphy demonstrated diffuse pulmonary uptake, suggesting metastatic disease. However, subsequent pathologic, biochemical and radiographic testing proved that she was in fact disease free, and the initial 123I pulmonary uptake was identified as a false positive. Inflammatory conditions may rarely cause iodine uptake in non-thyroidal tissues due to local retention, organification, and/or immunologic utilization. To avoid exposing patients to unnecessary treatments, it is critical for clinicians to recognize that comorbid pulmonary conditions may mimic metastatic PTC on radioiodine scintigraphy.

KW - False-positive reactions

KW - IgA deficiency

KW - Papillary thyroid carcinoma

KW - Radionuclide imaging

KW - Scintigraphy

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DO - 10.1007/s13139-015-0375-8

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False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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