Familial amyloidosis of Ostertag

J. G. Lanham, M. L. Meltzer, F. C. de Beer, G. R. Hughes, M. B. Pepys

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


A 23 year old Englishman presented with keratoconjunctivitis sicca and was found to have systemic amyloidosis. Five members of his family in two generations also had non-neuropathic amyloid particularly affecting the kidneys. This confirms to the Ostertag type of heredidatary amyloidosis. Amyloid deposits in the proband showed permanganate-sensitive Congophilia and positive immunofluorescence staining for P component, but were negative for amyloid A and prealbumin. These observations suggested that the fibril protein in this patient was immunochemically distinct from the amyloid fibrils characterized hitherto.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalQuarterly Journal of Medicine
Issue number201
StatePublished - 1982

ASJC Scopus subject areas

  • Medicine (all)


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