Feasibility of collecting saliva for biological verification of tobacco use status in dental practices and patients’ homes: Results from the national dental PBRN

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3 Scopus citations


Objective: To evaluate the feasibility of collecting and analyzing saliva samples from dental practices and patients’ homes for biochemical verification of tobacco use status. Basic research design: Sub-study within single-arm, multi-center, longitudinal clinical study. Clinical setting: Dental practices in the South Central region of the United States National Dental Practice-Based Research Network and patients’ homes. Participants: Fifty-five patients recruited from 30 dental practices. Interventions: Participants in the sub-study were instructed on saliva collection for cotinine analysis in dental practices where they enrolled in the primary study. Saliva was collected at the practices and then from patients’ homes. Main outcome measures: Feasibility for dental practice collection was define as 80% of enrolled participants having analyzable samples. For patients’ home collection, feasibility was defined as 70%. Results: Forty-seven samples (i.e., 86% of those enrolled) collected in dental practices were analyzable. Twenty-one samples (i.e. 38% of those enrolled) collected in patients’ homes were analyzable. Conclusions: Collecting saliva samples for cotinine analysis from dental practices, but not from patients’ homes, was feasible. Dental practices may provide an advantageous setting for biochemically verifying tobacco use status as part of clinical trials for tobacco cessation.

Original languageEnglish
Pages (from-to)187-189
Number of pages3
JournalCommunity Dental Health
Issue number3
StatePublished - Sep 2019

Bibliographical note

Funding Information:
This project was funded by National Institutes of Health (NIH) grants R44-DE021327 and U19-DE022516. The authors gratefully acknowledge other Regional Coordinators who were involved with study development, protocol training of practitioners, and study implementation (Claudia Carcelén, MPH and Ellen Sowell, BA) as well as the network practice sites. Opinions and assertions contained herein are those of the authors and are not to be construed as necessarily representing the views of the respective organizations or the NIH. The informed consent of all human subjects who participated in this investigation was obtained after the nature of the procedures had been explained fully. This research was also supported by the Behavioral and Community-Based Research Shared Resource Facility (BCBR-SRF) of the University of Kentucky Markey Cancer Center (P30-CA177558). An Internet site devoted to details about the nation’s network is located at http://NationalDentalPBRN.org. Data collection forms, training instructions and a photograph of the saliva collection packet are available at http://nationaldentalpbrn.org/study-results/. The authors declare no conflicts of interest relevant to this work.

Publisher Copyright:
© BASCD 2019.


  • Cotinine
  • Dental practice
  • Feasibility
  • Saliva
  • Smoking cessation

ASJC Scopus subject areas

  • Dentistry (all)
  • Public Health, Environmental and Occupational Health


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