Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study

Scott S. Lee; Nicole Senft Everson; Maureen Sanderson; Rebecca Selove; William J. Blot; Stephen King; Karen Gilliam; Suman Kundu; Mark Steinwandel; Sarah J. Sternlieb; Qiuyin Cai; Shaneda Warren Andersen; Debra L. Friedman; Erin Connors Kelly; Mary Kay Fadden; Matthew S. Freiberg; Quinn S. Wells; Juan Canedo; Rachel F. Tyndale; Robert P. Young; Raewyn J. Hopkins; Hilary A. Tindle

doi:10.1186/s13722-024-00441-1

Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study

Scott S. Lee
, Nicole Senft Everson
, Maureen Sanderson
, Rebecca Selove
, William J. Blot
, Stephen King
, Karen Gilliam
, Suman Kundu
, Mark Steinwandel
, Sarah J. Sternlieb
, Qiuyin Cai
, Shaneda Warren Andersen
, Debra L. Friedman
, Erin Connors Kelly
, Mary Kay Fadden
, Matthew S. Freiberg
, Quinn S. Wells
, Juan Canedo
, Rachel F. Tyndale
, Robert P. Young

Raewyn J. Hopkins, Hilary A. Tindle

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: The feasibility of precision smoking treatment in socioeconomically disadvantaged communities has not been studied. Methods: Participants in the Southern Community Cohort Study who smoked daily were invited to join a pilot randomized controlled trial of three smoking cessation interventions: guideline-based care (GBC), GBC plus nicotine metabolism-informed care (MIC), and GBC plus counseling guided by a polygenic risk score (PRS) for lung cancer. Feasibility was assessed by rates of study enrollment, engagement, and retention, targeting > 70% for each. Using logistic regression, we also assessed whether feasibility varied by age, sex, race, income, education, and attitudes toward precision smoking treatment. Results: Of 92 eligible individuals (79.3% Black; 68.2% with household income < $15,000), 67 (72.8%; 95% CI 63.0–80.9%) enrolled and were randomized. Of these, 58 (86.6%; 95% CI 76.4–92.8%) engaged with the intervention, and of these engaged participants, 43 (74.1%; 95% CI 61.6–83.7%) were retained at 6-month follow-up. Conditional on enrollment, older age was associated with lower engagement (OR 0.83, 95% CI 0.73–0.95, p = 0.008). Conditional on engagement, retention was significantly lower in the PRS arm than in the GBC arm (OR 0.18, 95% CI 0.03–1.00, p = 0.050). No other selection effects were observed. Conclusions: Genetically informed precision smoking cessation interventions are feasible in socioeconomically disadvantaged communities, exhibiting high enrollment, engagement, and retention irrespective of race, sex, income, education, or attitudes toward precision smoking treatment. Future smoking cessation interventions in this population should take steps to engage older people and to sustain participation in interventions that include genetic risk counseling. Trial registration: ClinicalTrials.gov No. NCT03521141, Registered 27 April 2018, https://www.clinicaltrials.gov/study/NCT03521141.

Original language	English
Article number	16
Journal	Addiction Science and Clinical Practice
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s13722-024-00441-1
State	Published - Dec 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Funding

SWA acknowledges support of the University of Wisconsin-Madison Carbone Cancer Center, University of Wisconsin-Madison Office of Vice Chancellor for Research and Graduate Education, and the Wisconsin Alumni Research Foundation. MSF acknowledges support of the Dorothy and Laurence Grossman Chair in Cardiology. HAT acknowledges support of the William Anderson Spickard, Jr, MD, Chair in Medicine and the National Cancer Institute Moonshot Initiative (P30CA068485-22S3). RFT acknowledges support of a Canada Research Chair in Pharmacogenomics, the Canadian Institutes of Health Research (Foundation Grant FDN-154294), and the Centre for Addiction and Mental Health. This work was supported by the National Cancer Institute (U54CA163072-09S1 to principal investigator (PI) Harold L. Moses, sub-project 6540, PI Hilary A. Tindle; U54CA163069 to PI Samuel E. Adunyah, sub-project 6962, PI Maureen Sanderson; and U54CA163066 to PIs Baqar A. Husaini and Margaret M. Whalen, sub-project 6610, PI Rebecca Selove) and the National Center for Advancing Translational Sciences (UL1TR002243). The Southern Community Cohort Study is funded by the National Cancer Institute (R01CA92447 to PIs William J. Blot and Wei Zheng), including special allocations from the American Recovery and Reinvestment Act (R01CA092447-08S1). Scott S. Lee was supported by the National Heart, Lung, and Blood Institute (K12HL137943). Nicole Senft Everson was formerly with Vanderbilt University Medical Center and was supported by the Agency for Healthcare Research and Quality (T32HS026122). She is now employed by the National Cancer Institute. The opinions expressed by the authors are their own, and this material should not be interpreted as representing the official viewpoint of the U.S. Department of Health and Human Services, the National Institutes of Health or the National Cancer Institute.

Funders	Funder number
Wisconsin Alumni Research Foundation
Canada Research Chair in Pharmacogenomics
William Anderson Spickard
Centre for Addiction and Mental Health
Canadian Institutes of Health Research	FDN-154294
Agency for Healthcare Research and Quality	T32HS026122
National Childhood Cancer Registry – National Cancer Institute	U54CA163072-09S1, U54CA163066, U54CA163069
National Center for Advancing Translational Sciences (NCATS)	R01CA092447-08S1, UL1TR002243
National Heart, Lung, and Blood Institute (NHLBI)	K12HL137943
National Cancer Institute Moonshot Initiative	P30CA068485-22S3

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Health disparities
Precision medicine
Smoking cessation treatment

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

Access to Document

10.1186/s13722-024-00441-1

Cite this

Lee, S. S., Senft Everson, N., Sanderson, M., Selove, R., Blot, W. J., King, S., Gilliam, K., Kundu, S., Steinwandel, M., Sternlieb, S. J., Cai, Q., Warren Andersen, S., Friedman, D. L., Connors Kelly, E., Fadden, M. K., Freiberg, M. S., Wells, Q. S., Canedo, J., Tyndale, R. F., ... Tindle, H. A. (2024). Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study. Addiction Science and Clinical Practice, 19(1), Article 16. https://doi.org/10.1186/s13722-024-00441-1

@article{451f4eb2be304bdf9e3f874e7ad62094,

title = "Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study",

abstract = "Background: The feasibility of precision smoking treatment in socioeconomically disadvantaged communities has not been studied. Methods: Participants in the Southern Community Cohort Study who smoked daily were invited to join a pilot randomized controlled trial of three smoking cessation interventions: guideline-based care (GBC), GBC plus nicotine metabolism-informed care (MIC), and GBC plus counseling guided by a polygenic risk score (PRS) for lung cancer. Feasibility was assessed by rates of study enrollment, engagement, and retention, targeting > 70\% for each. Using logistic regression, we also assessed whether feasibility varied by age, sex, race, income, education, and attitudes toward precision smoking treatment. Results: Of 92 eligible individuals (79.3\% Black; 68.2\% with household income < \$15,000), 67 (72.8\%; 95\% CI 63.0–80.9\%) enrolled and were randomized. Of these, 58 (86.6\%; 95\% CI 76.4–92.8\%) engaged with the intervention, and of these engaged participants, 43 (74.1\%; 95\% CI 61.6–83.7\%) were retained at 6-month follow-up. Conditional on enrollment, older age was associated with lower engagement (OR 0.83, 95\% CI 0.73–0.95, p = 0.008). Conditional on engagement, retention was significantly lower in the PRS arm than in the GBC arm (OR 0.18, 95\% CI 0.03–1.00, p = 0.050). No other selection effects were observed. Conclusions: Genetically informed precision smoking cessation interventions are feasible in socioeconomically disadvantaged communities, exhibiting high enrollment, engagement, and retention irrespective of race, sex, income, education, or attitudes toward precision smoking treatment. Future smoking cessation interventions in this population should take steps to engage older people and to sustain participation in interventions that include genetic risk counseling. Trial registration: ClinicalTrials.gov No. NCT03521141, Registered 27 April 2018, https://www.clinicaltrials.gov/study/NCT03521141.",

keywords = "Health disparities, Precision medicine, Smoking cessation treatment",

author = "Lee, \{Scott S.\} and \{Senft Everson\}, Nicole and Maureen Sanderson and Rebecca Selove and Blot, \{William J.\} and Stephen King and Karen Gilliam and Suman Kundu and Mark Steinwandel and Sternlieb, \{Sarah J.\} and Qiuyin Cai and \{Warren Andersen\}, Shaneda and Friedman, \{Debra L.\} and \{Connors Kelly\}, Erin and Fadden, \{Mary Kay\} and Freiberg, \{Matthew S.\} and Wells, \{Quinn S.\} and Juan Canedo and Tyndale, \{Rachel F.\} and Young, \{Robert P.\} and Hopkins, \{Raewyn J.\} and Tindle, \{Hilary A.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1186/s13722-024-00441-1",

language = "English",

volume = "19",

number = "1",

}

Lee, SS, Senft Everson, N, Sanderson, M, Selove, R, Blot, WJ, King, S, Gilliam, K, Kundu, S, Steinwandel, M, Sternlieb, SJ, Cai, Q, Warren Andersen, S, Friedman, DL, Connors Kelly, E, Fadden, MK, Freiberg, MS, Wells, QS, Canedo, J, Tyndale, RF, Young, RP, Hopkins, RJ & Tindle, HA 2024, 'Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study', Addiction Science and Clinical Practice, vol. 19, no. 1, 16. https://doi.org/10.1186/s13722-024-00441-1

Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study. / Lee, Scott S.; Senft Everson, Nicole; Sanderson, Maureen et al.
In: Addiction Science and Clinical Practice, Vol. 19, No. 1, 16, 12.2024.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Feasibility of precision smoking treatment in a low-income community setting

T2 - results of a pilot randomized controlled trial in The Southern Community Cohort Study

AU - Lee, Scott S.

AU - Senft Everson, Nicole

AU - Sanderson, Maureen

AU - Selove, Rebecca

AU - Blot, William J.

AU - King, Stephen

AU - Gilliam, Karen

AU - Kundu, Suman

AU - Steinwandel, Mark

AU - Sternlieb, Sarah J.

AU - Cai, Qiuyin

AU - Warren Andersen, Shaneda

AU - Friedman, Debra L.

AU - Connors Kelly, Erin

AU - Fadden, Mary Kay

AU - Freiberg, Matthew S.

AU - Wells, Quinn S.

AU - Canedo, Juan

AU - Tyndale, Rachel F.

AU - Young, Robert P.

AU - Hopkins, Raewyn J.

AU - Tindle, Hilary A.

PY - 2024/12

Y1 - 2024/12

N2 - Background: The feasibility of precision smoking treatment in socioeconomically disadvantaged communities has not been studied. Methods: Participants in the Southern Community Cohort Study who smoked daily were invited to join a pilot randomized controlled trial of three smoking cessation interventions: guideline-based care (GBC), GBC plus nicotine metabolism-informed care (MIC), and GBC plus counseling guided by a polygenic risk score (PRS) for lung cancer. Feasibility was assessed by rates of study enrollment, engagement, and retention, targeting > 70% for each. Using logistic regression, we also assessed whether feasibility varied by age, sex, race, income, education, and attitudes toward precision smoking treatment. Results: Of 92 eligible individuals (79.3% Black; 68.2% with household income < $15,000), 67 (72.8%; 95% CI 63.0–80.9%) enrolled and were randomized. Of these, 58 (86.6%; 95% CI 76.4–92.8%) engaged with the intervention, and of these engaged participants, 43 (74.1%; 95% CI 61.6–83.7%) were retained at 6-month follow-up. Conditional on enrollment, older age was associated with lower engagement (OR 0.83, 95% CI 0.73–0.95, p = 0.008). Conditional on engagement, retention was significantly lower in the PRS arm than in the GBC arm (OR 0.18, 95% CI 0.03–1.00, p = 0.050). No other selection effects were observed. Conclusions: Genetically informed precision smoking cessation interventions are feasible in socioeconomically disadvantaged communities, exhibiting high enrollment, engagement, and retention irrespective of race, sex, income, education, or attitudes toward precision smoking treatment. Future smoking cessation interventions in this population should take steps to engage older people and to sustain participation in interventions that include genetic risk counseling. Trial registration: ClinicalTrials.gov No. NCT03521141, Registered 27 April 2018, https://www.clinicaltrials.gov/study/NCT03521141.

AB - Background: The feasibility of precision smoking treatment in socioeconomically disadvantaged communities has not been studied. Methods: Participants in the Southern Community Cohort Study who smoked daily were invited to join a pilot randomized controlled trial of three smoking cessation interventions: guideline-based care (GBC), GBC plus nicotine metabolism-informed care (MIC), and GBC plus counseling guided by a polygenic risk score (PRS) for lung cancer. Feasibility was assessed by rates of study enrollment, engagement, and retention, targeting > 70% for each. Using logistic regression, we also assessed whether feasibility varied by age, sex, race, income, education, and attitudes toward precision smoking treatment. Results: Of 92 eligible individuals (79.3% Black; 68.2% with household income < $15,000), 67 (72.8%; 95% CI 63.0–80.9%) enrolled and were randomized. Of these, 58 (86.6%; 95% CI 76.4–92.8%) engaged with the intervention, and of these engaged participants, 43 (74.1%; 95% CI 61.6–83.7%) were retained at 6-month follow-up. Conditional on enrollment, older age was associated with lower engagement (OR 0.83, 95% CI 0.73–0.95, p = 0.008). Conditional on engagement, retention was significantly lower in the PRS arm than in the GBC arm (OR 0.18, 95% CI 0.03–1.00, p = 0.050). No other selection effects were observed. Conclusions: Genetically informed precision smoking cessation interventions are feasible in socioeconomically disadvantaged communities, exhibiting high enrollment, engagement, and retention irrespective of race, sex, income, education, or attitudes toward precision smoking treatment. Future smoking cessation interventions in this population should take steps to engage older people and to sustain participation in interventions that include genetic risk counseling. Trial registration: ClinicalTrials.gov No. NCT03521141, Registered 27 April 2018, https://www.clinicaltrials.gov/study/NCT03521141.

KW - Health disparities

KW - Precision medicine

KW - Smoking cessation treatment

UR - https://www.scopus.com/pages/publications/85187913659

UR - https://www.scopus.com/pages/publications/85187913659#tab=citedBy

U2 - 10.1186/s13722-024-00441-1

DO - 10.1186/s13722-024-00441-1

M3 - Article

C2 - 38491559

AN - SCOPUS:85187913659

SN - 1940-0632

VL - 19

JO - Addiction Science and Clinical Practice

JF - Addiction Science and Clinical Practice

IS - 1

M1 - 16

ER -

Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this