Femoral resurfacing in young patients with hematologic cancer and osteonecrosis

Evguenia J. Karimova, Shesh N. Rai, Jianrong Wu, Lunetha Britton, Sue C. Kaste, Michael D. Neel

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Resurfacing hemiarthroplasties were performed to treat advanced osteonecrosis of 20 femoral heads in 14 patients (median age, 19.8 years; range, 15.1-27.4 years), treated for hematologic cancer in childhood or adolescence. Seven hips in five patients were revised to total hip arthroplasties (THA) because of pain; three of these showed radiographic loosening of the femoral head resurfacing component. The median time from resurfacing to revision was 2.4 years (range, 0.9-4.8 years). Marginal Cox-regression analysis, adjusting for correlations owing to bilateral involvement, showed positive association of revision-free survival of the prosthesis with patient's age; time from resurfacing to the end of anticancer therapy, end of glucocorticosteroid therapy; percentage of joint space at the last radiograph; and size of the lesion has a negative association with revision-free survival. Because of this study's exploratory nature, p values were not adjusted for the number of statistical comparisons. Among 14 patients, the probability of not requiring resurfacing prosthesis revision was 66% (SE, ±15%; 95% CI, 44%-100%) at 3 years. Osteonecrosis of the femoral head in young patients treated for hematologic cancer in childhood or adolescence poses a serious challenge to the orthopaedic surgeon. The data of this preliminary study suggest that in selected patients resurfacing hemiarthroplasty may delay the need for THA for 3-7 years. Level of Evidence: Level II, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.

Original languageEnglish
Pages (from-to)3044-3050
Number of pages7
JournalClinical Orthopaedics and Related Research
Issue number12
StatePublished - Dec 2008

Bibliographical note

Funding Information:
One or more authors (EJK, SCK, SNR, JW, LB, MDN) have received funding from the American Lebanese Syrian Associated Charities (ALSAC). Each author certifies that his or her institution has approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research.

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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