Fenbendazole treatment may influence lipopolysaccharide effects in rat brain

Randy L. Hunter, Dong Young Choi, Jeanie F. Kincer, Wayne A. Cass, Guoying Bing, Don M. Gash

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


In evaluating discrepant results between experiments in our laboratory, we collected data that challenge the notion that anthelminthic drugs like FBZ do not alter inflammatory responses. We found that FBZ significantly modulates inflammation in F344 rats intrastriatally injected with LPS. FBZ treatment of LPS-injected rats significantly increased weight loss, microglial activation, and dopamine loss; in addition, FBZ attenuated the LPS-induced loss of astrocytes. Therefore, FBZ treatment altered the effects of LPS injection. Caution should be used in interpreting data collected from rats treated with LPS and FBZ.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalComparative Medicine
Issue number5
StatePublished - Oct 2007

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Veterinary


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