Fenbendazole treatment may influence lipopolysaccharide effects in rat brain

Randy L. Hunter; Dong Young Choi; Jeanie F. Kincer; Wayne A. Cass; Guoying Bing; Don M. Gash

Fenbendazole treatment may influence lipopolysaccharide effects in rat brain

Randy L. Hunter, Dong Young Choi, Jeanie F. Kincer, Wayne A. Cass, Guoying Bing, Don M. Gash

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

In evaluating discrepant results between experiments in our laboratory, we collected data that challenge the notion that anthelminthic drugs like FBZ do not alter inflammatory responses. We found that FBZ significantly modulates inflammation in F344 rats intrastriatally injected with LPS. FBZ treatment of LPS-injected rats significantly increased weight loss, microglial activation, and dopamine loss; in addition, FBZ attenuated the LPS-induced loss of astrocytes. Therefore, FBZ treatment altered the effects of LPS injection. Caution should be used in interpreting data collected from rats treated with LPS and FBZ.

Original language	English
Pages (from-to)	487-492
Number of pages	6
Journal	Comparative Medicine
Volume	57
Issue number	5
State	Published - Oct 2007

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Veterinary

Cite this

@article{a05e4d925c7b4e419ddaa3612637652f,

title = "Fenbendazole treatment may influence lipopolysaccharide effects in rat brain",

abstract = "In evaluating discrepant results between experiments in our laboratory, we collected data that challenge the notion that anthelminthic drugs like FBZ do not alter inflammatory responses. We found that FBZ significantly modulates inflammation in F344 rats intrastriatally injected with LPS. FBZ treatment of LPS-injected rats significantly increased weight loss, microglial activation, and dopamine loss; in addition, FBZ attenuated the LPS-induced loss of astrocytes. Therefore, FBZ treatment altered the effects of LPS injection. Caution should be used in interpreting data collected from rats treated with LPS and FBZ.",

author = "Hunter, {Randy L.} and Choi, {Dong Young} and Kincer, {Jeanie F.} and Cass, {Wayne A.} and Guoying Bing and Gash, {Don M.}",

year = "2007",

month = oct,

language = "English",

volume = "57",

pages = "487--492",

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T1 - Fenbendazole treatment may influence lipopolysaccharide effects in rat brain

AU - Hunter, Randy L.

AU - Choi, Dong Young

AU - Kincer, Jeanie F.

AU - Cass, Wayne A.

AU - Bing, Guoying

AU - Gash, Don M.

PY - 2007/10

Y1 - 2007/10

N2 - In evaluating discrepant results between experiments in our laboratory, we collected data that challenge the notion that anthelminthic drugs like FBZ do not alter inflammatory responses. We found that FBZ significantly modulates inflammation in F344 rats intrastriatally injected with LPS. FBZ treatment of LPS-injected rats significantly increased weight loss, microglial activation, and dopamine loss; in addition, FBZ attenuated the LPS-induced loss of astrocytes. Therefore, FBZ treatment altered the effects of LPS injection. Caution should be used in interpreting data collected from rats treated with LPS and FBZ.

AB - In evaluating discrepant results between experiments in our laboratory, we collected data that challenge the notion that anthelminthic drugs like FBZ do not alter inflammatory responses. We found that FBZ significantly modulates inflammation in F344 rats intrastriatally injected with LPS. FBZ treatment of LPS-injected rats significantly increased weight loss, microglial activation, and dopamine loss; in addition, FBZ attenuated the LPS-induced loss of astrocytes. Therefore, FBZ treatment altered the effects of LPS injection. Caution should be used in interpreting data collected from rats treated with LPS and FBZ.

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M3 - Article

C2 - 17974132

AN - SCOPUS:38449088108

SN - 1532-0820

VL - 57

SP - 487

EP - 492

JO - Comparative Medicine

JF - Comparative Medicine

IS - 5

ER -

Fenbendazole treatment may influence lipopolysaccharide effects in rat brain

Abstract

ASJC Scopus subject areas

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