TY - JOUR
T1 - Fetal brain progenitor cells transdifferentiate to fates outside the nervous system
AU - Sang U, Hoi
AU - Alilain, Warren
AU - Saljooque, Farid
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Central nervous system stem cells give rise to neurons and glia when exposed to specific trophic factors. In our studies with rat fetal brain-derived stem cells (RSCs), we showed that they could be induced to express the developmentally regulated transcription factors and cell markers characteristic of cells derived from another germ layer, e.g. pituitary cells. Therefore, rat fetal brain-derived stem cells do not seem to be restricted to a defined developmental fate. They may retain pluripotentiality and can be redirected to develop into other cell types not found in the brain provided the correct set of stimuli is present. This multipotent developmental behavior also suggests that instructive signals are operative.
AB - Central nervous system stem cells give rise to neurons and glia when exposed to specific trophic factors. In our studies with rat fetal brain-derived stem cells (RSCs), we showed that they could be induced to express the developmentally regulated transcription factors and cell markers characteristic of cells derived from another germ layer, e.g. pituitary cells. Therefore, rat fetal brain-derived stem cells do not seem to be restricted to a defined developmental fate. They may retain pluripotentiality and can be redirected to develop into other cell types not found in the brain provided the correct set of stimuli is present. This multipotent developmental behavior also suggests that instructive signals are operative.
UR - http://www.scopus.com/inward/record.url?scp=0036841844&partnerID=8YFLogxK
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U2 - 10.1210/me.2002-0094
DO - 10.1210/me.2002-0094
M3 - Article
C2 - 12403852
AN - SCOPUS:0036841844
SN - 0888-8809
VL - 16
SP - 2645
EP - 2656
JO - Molecular Endocrinology
JF - Molecular Endocrinology
IS - 11
ER -