Fever and the acute elevation in whole-body thermogenesis induced by lateral hypothalamic lesions

Terry A. Lennie, Matt D. Hirvonen, Donna O. McCarthy, Richard E. Keesey

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Three studies investigated the role of fever in the acute elevation of heat production induced by lateral hypothalamic (LH) lesions and the mechanisms by which this thermogenic response can be attenuated by reductions in body weight. In Study 1, reducing the weights of rats prior to lesioning the LH attenuated both the usual postlesion fever and elevation in thermogenesis. In Study 2, blocking prostaglandin synthesis with indomethacin likewise blunted both the lesion-induced fever and thermogenesis. In Study 3, treating already weight-reduced rats with indomethacin attenuated, but still failed to eliminate, the lesion-induced fever. Together, these results suggest that both the fever and increased thermogenesis induced by LH lesions are mediated, at least in part, by prostaglandin mechanisms which themselves are influenced by body energy status.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalPhysiology and Behavior
Issue number2
StatePublished - Aug 1995

Bibliographical note

Funding Information:
ACKNOWLEDGEMENT Support for this research was provided by NRSA Predoctoral Fellowship 5 F31 NR06420 from the NCNR, and NIH grant DK 19944.


  • Body weight
  • Core temperature
  • Fever
  • Heat production
  • Lateral hypothalamic lesions
  • Oxygen consumption Indomethacin
  • Rat

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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