TY - JOUR
T1 - FiberSim
T2 - A flexible open-source model of myofilament-level contraction
AU - Kosta, Sarah
AU - Colli, Dylan
AU - Ye, Qiang
AU - Campbell, Kenneth S.
N1 - Publisher Copyright:
© 2021 Biophysical Society
PY - 2022/1/18
Y1 - 2022/1/18
N2 - FiberSim is a flexible open-source model of myofilament-level contraction. The code uses a spatially explicit technique, meaning that it tracks the position and status of each contractile molecule within the lattice framework. This allows the model to simulate some of the mechanical effects modulated by myosin-binding protein C, as well as the dose dependence of myotropes and the effects of varying isoform expression levels. This paper provides a short introduction to FiberSim and presents simulations of tension-pCa curves with and without regulation of thick and thin filament activation by myosin-binding protein C. A myotrope dose-dependent response as well as slack/re-stretch maneuvers to assess rates of tension recovery are also presented. The software was designed to be flexible (the user can define their own model and/or protocol) and computationally efficient (simulations can be performed on a regular laptop). We hope that other investigators will use FiberSim to explore myofilament level mechanisms and to accelerate research focusing on the contractile properties of sarcomeres.
AB - FiberSim is a flexible open-source model of myofilament-level contraction. The code uses a spatially explicit technique, meaning that it tracks the position and status of each contractile molecule within the lattice framework. This allows the model to simulate some of the mechanical effects modulated by myosin-binding protein C, as well as the dose dependence of myotropes and the effects of varying isoform expression levels. This paper provides a short introduction to FiberSim and presents simulations of tension-pCa curves with and without regulation of thick and thin filament activation by myosin-binding protein C. A myotrope dose-dependent response as well as slack/re-stretch maneuvers to assess rates of tension recovery are also presented. The software was designed to be flexible (the user can define their own model and/or protocol) and computationally efficient (simulations can be performed on a regular laptop). We hope that other investigators will use FiberSim to explore myofilament level mechanisms and to accelerate research focusing on the contractile properties of sarcomeres.
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U2 - 10.1016/j.bpj.2021.12.021
DO - 10.1016/j.bpj.2021.12.021
M3 - Article
C2 - 34932957
AN - SCOPUS:85122649104
SN - 0006-3495
VL - 121
SP - 175
EP - 182
JO - Biophysical Journal
JF - Biophysical Journal
IS - 2
ER -