FiberSim: A flexible open-source model of myofilament-level contraction

Sarah Kosta, Dylan Colli, Qiang Ye, Kenneth S. Campbell

Research output: Contribution to journalArticlepeer-review

Abstract

FiberSim is a flexible open-source model of myofilament-level contraction. The code uses a spatially explicit technique, meaning that it tracks the position and status of each contractile molecule within the lattice framework. This allows the model to simulate some of the mechanical effects modulated by myosin-binding protein C, as well as the dose dependence of myotropes and the effects of varying isoform expression levels. This paper provides a short introduction to FiberSim and presents simulations of tension-pCa curves with and without regulation of thick and thin filament activation by myosin-binding protein C. A myotrope dose-dependent response as well as slack/re-stretch maneuvers to assess rates of tension recovery are also presented. The software was designed to be flexible (the user can define their own model and/or protocol) and computationally efficient (simulations can be performed on a regular laptop). We hope that other investigators will use FiberSim to explore myofilament level mechanisms and to accelerate research focusing on the contractile properties of sarcomeres.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalBiophysical Journal
Volume121
Issue number2
DOIs
StatePublished - Jan 18 2022

Bibliographical note

Funding Information:
Supported by NIH HL146676 , HL148785 , TR0001998 , and AHA TP135689 to KSC, by AHA 829744 to SK, and by NSF DMS-1821144 to QY.

Publisher Copyright:
© 2021 Biophysical Society

ASJC Scopus subject areas

  • Biophysics

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