Fidelity of the PINK1 knockout rat to oxidative stress and other characteristics of Parkinson disease

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Parkinson disease (PD) is the second most common age-related neurodegenerative disease in the world, and PD significantly impacts the quality of life, especially as in general people are living longer. Because of the numerous and complex features of sporadic PD that progressively develops, it is difficult to build an ideal animal model for PD research. Genetically modified PD rodent animal models are considered as a major tool with which to study the mechanisms and potential therapeutic targets for PD. Up to now, none of the rodent animal models displays all PD characteristics. The Michael J. Fox Foundation for Parkinson's Research (MJFF) funded SAGE Laboratories to generate a PTEN-induced putative kinase-1 (PINK1) knockout (KO) rat model for familial PD using zinc finger nuclease (ZFN) technology. In the current paper, we review all papers from PubMed that report studies with PINK1 KO rats, presenting the research results, and discussing the fidelity of this rat model to PD according to its phenotypes studied by several laboratories. This review will serve as a critical reference for future studies with this rodent model, providing a better understanding of PD etiology, pathology, and potential treatment strategies.

Original languageEnglish
Pages (from-to)88-101
Number of pages14
JournalFree Radical Biology and Medicine
Volume163
DOIs
StatePublished - Feb 1 2021

Bibliographical note

Funding Information:
This work was supported in part by a grant [ NS094891 ] from the National Institutes of Health to D.A.B. Opinions expressed in this manuscript are not necessarily those of the National Institutes of Health.

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

  • Oxidative stress
  • PINK1 knockout rat
  • Parkinson disease

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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