Fish oil-containing multicomponent lipid emulsion vs soy-based lipid emulsion and neurodevelopmental outcomes of children born < 29 weeks’ gestation

Ranjit Torgalkar; Jyotsna Shah; Shruti Dave; Junmin Yang; Nastaran Ostad; Kirsten Kotsopoulos; Sharon Unger; Edmond Kelly; Prakesh S. Shah

doi:10.1038/s41372-020-0710-5

Fish oil-containing multicomponent lipid emulsion vs soy-based lipid emulsion and neurodevelopmental outcomes of children born < 29 weeks’ gestation

Ranjit Torgalkar, Jyotsna Shah, Shruti Dave, Junmin Yang, Nastaran Ostad, Kirsten Kotsopoulos, Sharon Unger, Edmond Kelly, Prakesh S. Shah

Pediatrics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Objective: To compare neurodevelopmental outcomes of extremely preterm children who received soy-medium chain triglycerides-olive-fish oil-containing lipid emulsion (SMOF-LE) vs soy-based LE. Study design: We conducted a pre-post comparative cohort study of children born < 29 weeks’ gestation who received > 7 days of LE. Outcomes were mortality/significant neurodevelopmental impairment (NDI), mortality/any NDI, significant NDI, any NDI, and individual components of NDI. Results: Among children with follow-up data (Intralipid: n = 340/442, 77%; SMOF-LE: n = 214/286, 75%), baseline characteristics were comparable except for postnatal steroids. There was no significant difference in death/significant NDI between groups. Adjusted odds of death/any NDI [0.68 (95% CI 0.48, 0.97)], any NDI [0.64 (95% CI 0.44, 0.93)] and Bayley-III language score < 85 and <70 were significantly lower in the SMOF-LE group. Conclusions: In extremely preterm children, a change from soy-based LE to SMOF-LE was not associated with deleterious effect on neurodevelopmental outcomes and may have been associated with some improvement.

Original language	English
Pages (from-to)	1712-1718
Number of pages	7
Journal	Journal of Perinatology
Volume	40
Issue number	11
DOIs	https://doi.org/10.1038/s41372-020-0710-5
State	Published - Nov 1 2020

Bibliographical note

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

Funding

Acknowledgements The authors thank Heather McDonald-Kinkaid, Ph.D., of the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital, Toronto, ON, Canada, for editorial support in preparing this paper. MiCare is supported by a Canadian Institutes of Health Research Team Grant (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and the participating hospitals.

Funders	Funder number
Ontario Ministry of Health and Long-Term Care Academic Health Sciences Centres Alternate Funding Plan Innovation Fund, Canada
Canadian Institutes of Health Research	CTP 87518, APR-126340

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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Cite this

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title = "Fish oil-containing multicomponent lipid emulsion vs soy-based lipid emulsion and neurodevelopmental outcomes of children born < 29 weeks{\textquoteright} gestation",

abstract = "Objective: To compare neurodevelopmental outcomes of extremely preterm children who received soy-medium chain triglycerides-olive-fish oil-containing lipid emulsion (SMOF-LE) vs soy-based LE. Study design: We conducted a pre-post comparative cohort study of children born < 29 weeks{\textquoteright} gestation who received > 7 days of LE. Outcomes were mortality/significant neurodevelopmental impairment (NDI), mortality/any NDI, significant NDI, any NDI, and individual components of NDI. Results: Among children with follow-up data (Intralipid: n = 340/442, 77\%; SMOF-LE: n = 214/286, 75\%), baseline characteristics were comparable except for postnatal steroids. There was no significant difference in death/significant NDI between groups. Adjusted odds of death/any NDI [0.68 (95\% CI 0.48, 0.97)], any NDI [0.64 (95\% CI 0.44, 0.93)] and Bayley-III language score < 85 and <70 were significantly lower in the SMOF-LE group. Conclusions: In extremely preterm children, a change from soy-based LE to SMOF-LE was not associated with deleterious effect on neurodevelopmental outcomes and may have been associated with some improvement.",

author = "Ranjit Torgalkar and Jyotsna Shah and Shruti Dave and Junmin Yang and Nastaran Ostad and Kirsten Kotsopoulos and Sharon Unger and Edmond Kelly and Shah, \{Prakesh S.\}",

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AU - Shah, Jyotsna

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AU - Yang, Junmin

AU - Ostad, Nastaran

AU - Kotsopoulos, Kirsten

AU - Unger, Sharon

AU - Kelly, Edmond

AU - Shah, Prakesh S.

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N2 - Objective: To compare neurodevelopmental outcomes of extremely preterm children who received soy-medium chain triglycerides-olive-fish oil-containing lipid emulsion (SMOF-LE) vs soy-based LE. Study design: We conducted a pre-post comparative cohort study of children born < 29 weeks’ gestation who received > 7 days of LE. Outcomes were mortality/significant neurodevelopmental impairment (NDI), mortality/any NDI, significant NDI, any NDI, and individual components of NDI. Results: Among children with follow-up data (Intralipid: n = 340/442, 77%; SMOF-LE: n = 214/286, 75%), baseline characteristics were comparable except for postnatal steroids. There was no significant difference in death/significant NDI between groups. Adjusted odds of death/any NDI [0.68 (95% CI 0.48, 0.97)], any NDI [0.64 (95% CI 0.44, 0.93)] and Bayley-III language score < 85 and <70 were significantly lower in the SMOF-LE group. Conclusions: In extremely preterm children, a change from soy-based LE to SMOF-LE was not associated with deleterious effect on neurodevelopmental outcomes and may have been associated with some improvement.

AB - Objective: To compare neurodevelopmental outcomes of extremely preterm children who received soy-medium chain triglycerides-olive-fish oil-containing lipid emulsion (SMOF-LE) vs soy-based LE. Study design: We conducted a pre-post comparative cohort study of children born < 29 weeks’ gestation who received > 7 days of LE. Outcomes were mortality/significant neurodevelopmental impairment (NDI), mortality/any NDI, significant NDI, any NDI, and individual components of NDI. Results: Among children with follow-up data (Intralipid: n = 340/442, 77%; SMOF-LE: n = 214/286, 75%), baseline characteristics were comparable except for postnatal steroids. There was no significant difference in death/significant NDI between groups. Adjusted odds of death/any NDI [0.68 (95% CI 0.48, 0.97)], any NDI [0.64 (95% CI 0.44, 0.93)] and Bayley-III language score < 85 and <70 were significantly lower in the SMOF-LE group. Conclusions: In extremely preterm children, a change from soy-based LE to SMOF-LE was not associated with deleterious effect on neurodevelopmental outcomes and may have been associated with some improvement.

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Fish oil-containing multicomponent lipid emulsion vs soy-based lipid emulsion and neurodevelopmental outcomes of children born < 29 weeks’ gestation

Abstract

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ASJC Scopus subject areas

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