Five naturally bioactive molecules including two rhamnopyranoside derivatives isolated from the Streptomyces sp. strain TN58

Raoudha Ben Ameur Mehdi, Khaled A. Shaaban, Ines Karray Rebai, Slim Smaoui, Samir Bejar, Lotfi Mellouli

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Extraction of 25 L fermentation broth of the newly isolated Streptomyces sp. strain TN58 and various separation and purification steps led to the isolation of five bioactive metabolites, namely brevianamide F (C1), reported from a streptomycete for the first time, N-acetyltryptamine (C2), thiazolidomycin (C3), and two rhamnopyranosides (C4 and C5). These two rhamnopyranosides were produced directly, without precursor addition. The chemical structure of these five active compounds was established on the basis of 1H, 13C/APT and 2D NMR spectra, ESI and EI-MS data, and by comparison with data from the literature. According to the biological studies, we show in this work that the compounds C1, C2, C4 and C5 possess antimicrobial activities.

Original languageEnglish
Pages (from-to)1095-1107
Number of pages13
JournalNatural Product Research
Volume23
Issue number12
DOIs
StatePublished - Jan 2009

Keywords

  • Antimicrobial activities
  • Chemical structure
  • Purification
  • Rhamnopyranoside derivatives
  • Streptomyces sp. TN58

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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